Correlation of Sonographic Grading of Fatty Changes of Liver with Lipid Profile:

Chidananda Murthy. M; M. V. Karthik; Ganesh K; Francis N. P. Monteiro

Chidananda Murthy. M Assistant Professor, Department of Radio-Diagnosis, A.J. Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore -575004.
M. V. Karthik Assistant Professor, Department of Radio-Diagnosis, A.J. Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore -575004.
Ganesh K Professor & HOD, Department of Radio-Diagnosis, A.J. Institute of Medical Sciences and Research Centre, Kuntikana, Mangalore -575004.
Francis N. P. Monteiro Professor, Department of Forensic Medicine & Toxicology, A.J. Institute of Medical Sciences and Research Centre, NH 17, Kuntikana, Mangalore -575004.

Abstract

Background: Ultrasound Imaging can be used as a painless, non-invasive modality for the detection of nonalcoholic fatty liver disease (NAFLD) Aims: To determine the association of abnormal lipid profiles in persons identified with NAFLD using ultrasound. Settings and Design: Retrospective observational study design at a single Centre. Subjects and Methods: The study included subjects aged 20 to 70 years, identified with NAFLD based on ultrasound findings, with biochemical test results of lipid profile and with NAFLD graded based on ultrasound findings. Statistical Analysis used: A one way Analysis of Variation test (ANOVA) was used to compare the lipid profiles by grades of NAFLD. The lipid profiles were also categorized as optimal or normal and abnormal values and compared by grades of NAFLD. A p value of <0.05 was considered as statistically significant. Results: The study included 100 subjects (males=87) with a mean age of 46.1 11.2 years. Eighty nine subjects were categorized as grade I NAFLD, 9 as grade 2 NAFLD and 2 subjects as Grade III NAFLD. The mean SD total cholesterol was 195.55 43.78, serum triglycerides was 190.09122.03, HDL was 42.1410.75, and LDL was 120.4736.58 md/dL, cholesterol HDL ratio was 4.901.52 and LDL HDL ratio was 2.921.07 (range 0.56 to 5) in the study subjects. Thirty three (33.0%) of subjects had borderline high total cholesterol and 15 (15.0%) subjects had high total cholesterol. Twenty two (22.0%) subjects had borderline high serum triglycerides and 33 (33.0%) subjects had high serum triglycerides. Conclusion: An increasing dyslipidaemia was noticed with increasing severity of NAFLD graded using ultrasound imaging.

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