Morphometric Analysis of Corpus Callosum in Patients with Hypoxic Ischemic Encephalopathy (HIE)
Morphometric Analysis of Corpus Callosum in Patients with Hypoxic Ischemic Encephalopathy (HIE)
Abstract
Background: Corpus callosum (CC)- largest white matter structure in brain and has an important role in communicating both cerebral hemispheres. Damage to CC during development has been associated with poor neurological outcome, poor neuropsychological performance, cognitive and communication developmental delays.Aim and Objectives: Morphometric analysis of Corpus Callosum (CC) in HIE patients in comparison with CC of normal subjects by using MRI.Subjects and Methods: Retrospective comparative study of 40 patients-Ages < 2 year. Cases(20patients)-diagnosed cases of HIE on MRI. Controls (20patients)-proven to be normal on MRI. Two groups- ?1 year and 1- 2 year age-group. Study was done on T1-mid-sagittal sections of brain obtained on PHILIPS-Achieva 1.5-Tesla-MRI.Statistical Data analysis of different measurements was done usingt test and p values. Results&Conclusion: Variables were affected in order of Splenium>Body>Genu >Isthmus in ?1year age-group and Genu>Splenium>Body>Isthmus in >1year age-group when mean value of different variables were compared between cases and controls. In HIE cases, thickest part was Genu and thinnest part was Isthmus.No statistically significant difference was found between males and females. This is one of the few studies providing biometric comparison between the CC of HIE patients and their controls. Damage to the CC during development is associated with poor neurological and neuropsychological performance, cognitive and communication developmental delays. This study analyzes the pattern of involvement of different variables of CC in HIE patients and helps in predicting the poor neurological outcome and developmental delays.