Pre-Operative Testosterone Stimulation Does Not Improve Outcome in Distal and Mid Shaft Hypospadias Repair: A Prospective Study from A Tertiary Hospital in Bangladesh

Pre-Operative Testosterone Stimulation Does Not Improve Outcome in Distal and Mid Shaft Hypospadias Repair

  • Adnan Walid Specialist, Department of Pediatric Surgery, Imperial Hospital Limited, Chittagong, Bangladesh
  • Md Tameem Shafayat Chowdhury Resident Surgeon, Department of Pediatric Surgery, Chattogram Maa-O-Shishu Hospital Medical College, Bangladesh https://orcid.org/0000-0003-1205-5538
  • Tanzil Farhad Assistant Registrar, Department of Pediatric Surgery, Chittagong Medical College, Bangladesh https://orcid.org/0000-0002-0058-9025
  • Md Sharif Imam Assistant Professor, Department of Pediatric Surgery, Chattogram Maa Shishu-O-General Hospital, Bangladesh
  • Ayesha Sadia Department of Pediatric Surgery, Chittagong Medical College, Bangladesh
  • Mymoon Redwan Chowdhury MS (Final Part) Trainee, Department of Urology, Chittagong Medical College, Bangladesh
  • Rumana Khan Registrar, Department of Pediatric Surgery, Chittagong Medical College, Bangladesh
  • Anik Dawre MS Phase B trainee, Department of Pediatric Surgery, Chittagong Medical College, Bangladesh
  • Effat Sharmin Assistant Registrar, Department of Pediatric Surgery, Chittagong Medical College, Bangladesh
Keywords: Hypospadias, Testosterone, Tubularized incised plate urethroplasty, UC fistula

Abstract

Background: There are controversies about the use of pre-operative hormonal stimulation for hypospadias repair. This study aims at assessing complications following use of pre-operative testosterone injection for distal and mid shaft hypospadias. Subjects and Methods: In this prospective comparative study 51 patients were divided into group A: received pre-operative testosterone and group B: did not receive preoperative testosterone. All underwent tubularized incised plate urethroplasty and were followed up for 6 months after operation to observe for the development of complications. The groups were compared with T test, Man Whitney U test, Chi square test or Fisher exact test where appropriate. Results: There were 15 patients in group A and 36 patients in group B. Mean age was 6.59 ± 3.96 years in group A and 6.86 ± 3.32 years in group B (P=0.81). Eleven patients (73.3%) received single dose of testosterone while 3 (20%) and 1 (6.7%) patients received 2 and 3 doses respectively. Sub-coronal hypospadias, 21 (41.18%) was the most common variety followed by distal penile, 18 (35.29%) and mid penile, 12 (23.53%) hypospadias. Patients who received testosterone developed more complications (7 patients, 46.67%) than patients who did not receive testosterone (12 patients, 33.33%). However, this difference was not statistically significant (P=0.48). Urethro-cutaneous fistula was the most common complications in both groups. Conclusion: Preoperative testosterone injection does not improve outcome in distal and mid shaft hypospadias repair.

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Published
2022-04-16
How to Cite
Adnan Walid, Md Tameem Shafayat Chowdhury, Tanzil Farhad, Md Sharif Imam, Ayesha Sadia, Mymoon Redwan Chowdhury, Rumana Khan, Anik Dawre, & Effat Sharmin. (2022). Pre-Operative Testosterone Stimulation Does Not Improve Outcome in Distal and Mid Shaft Hypospadias Repair: A Prospective Study from A Tertiary Hospital in Bangladesh. Asian Journal of Clinical Pediatrics and Neonatology, 10(1), 8-12. Retrieved from https://aijournals.com/index.php/ajcpn/article/view/2290
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Original Article