Asian Journal of Clinical Pediatrics and Neonatology <p><strong class="pull-left">Asian Journal of Clinical Pediatrics and Neonatology (AJCPN)</strong>&nbsp;&nbsp;is an open-access; freely accessible, online and print Quarterly peer-reviewed international journal publishes a wide spectrum of advanced research in different fields of pediatrics and neonatology, covering etiology, diagnosis, therapy and prognosis aspects. <br><strong>Online ISSN: 2347-3363 | Print ISSN: 2347-3355</strong></p> en-US (Dr. Rohit Varshney) (Mr Shadan Pasha) Sat, 16 Apr 2022 06:12:43 +0000 OJS 60 Immunotherapy in NORSE- A Case Report <p>We present the case of a healthy five-year-old girl who presented with fever followed by refractory status epilepticus. Admitted to the intensive care unit, was managed with intravenous midazolam and first line antiepileptic drugs in loading doses. Seizure continued even then, so other antiepileptic medications were titrated to therapeutic doses. Intravenous acyclovir added in view of possibility of viral encephalitis. She also received high dose intravenous methyl prednisolone. Complete remission of seizure can’t be achieved in spite of several antiepileptic drugs. Lastly Intravenous immunoglobulin administered which caused dramatic improvement in clinical condition and complete seizure control. Laboratory investigation including autoimmune and paraneoplastic studies, CSF analysis yielded negative results. MRI brain nothing significant. Our case fulfils the definition of new-onset refractory status epilepticus (NORSE).</p> Anjani Bala , Manoj Kumar Singh, Abhishek Kumar , Munish Kumar Copyright (c) 2022 Author Sat, 16 Apr 2022 00:00:00 +0000 A Ruptured Sigmoid Mesocolon Hemangioma Presenting as Acute Abdomen: A Case Report and Review <p>Hemangiomas of the GI tract and mesentery are uncommon benign vascular lesions. While spontaneous bleeding distinguishes the gastrointesti- nal tumor variant, clinical signs of mesenteric hemangiomas are generally nonspecific. In the majority of cases, despite advances in imaging technology, surgery and histopathological analysis are still used to make final diagnoses. We present a case report of a 13-year-old female patient who was admitted with progressive lower abdominal pain and distension and suffered from persistent abdominal pain for 04 days. An irregular hypo-echoic area noted in left iliac fossa suggestive of bowel mass was detected on the ultrasound scan. Due to sonographic signs of an intraabdominal bowel mass, a diagnostic laparoscopy was performed, which revealed a large ruptured hemangioma originating from the sigmoid mesocolon. Although uncommon, pediatric surgeons should consider gastrointestinal hemangiomas as a possible differential diagnosis for large intraabdominal tumorous masses, particularly in young adults.</p> Adnan Walid , Utpak Das , Dil Anziz , Saiful Islam , Mymoon Redwan Chowdhury , Utpol Chowdhury , Puspita Chowdhury , Effat Sharmin , Arunabha Mallick , Raju Das , Adnan Bin Saleh Copyright (c) 2022 Author Sat, 16 Apr 2022 00:00:00 +0000 Pre-Operative Testosterone Stimulation Does Not Improve Outcome in Distal and Mid Shaft Hypospadias Repair: A Prospective Study from A Tertiary Hospital in Bangladesh <p>Background: There are controversies about the use of pre-operative hormonal stimulation for hypospadias repair. This study aims at assessing complications following use of pre-operative testosterone injection for distal and mid shaft hypospadias. Subjects and Methods: In this prospective comparative study 51 patients were divided into group A: received pre-operative testosterone and group B: did not receive preoperative testosterone. All underwent tubularized incised plate urethroplasty and were followed up for 6 months after operation to observe for the development of complications. The groups were compared with T test, Man Whitney U test, Chi square test or Fisher exact test where appropriate. Results: There were 15 patients in group A and 36 patients in group B. Mean age was 6.59 ± 3.96 years in group A and 6.86 ± 3.32 years in group B (P=0.81). Eleven patients (73.3%) received single dose of testosterone while 3 (20%) and 1 (6.7%) patients received 2 and 3 doses respectively. Sub-coronal hypospadias, 21 (41.18%) was the most common variety followed by distal penile, 18 (35.29%) and mid penile, 12 (23.53%) hypospadias. Patients who received testosterone developed more complications (7 patients, 46.67%) than patients who did not receive testosterone (12 patients, 33.33%). However, this difference was not statistically significant (P=0.48). Urethro-cutaneous fistula was the most common complications in both groups. Conclusion: Preoperative testosterone injection does not improve outcome in distal and mid shaft hypospadias repair.</p> Adnan Walid , Md Tameem Shafayat Chowdhury , Tanzil Farhad , Md Sharif Imam , Ayesha Sadia , Mymoon Redwan Chowdhury, Rumana Khan , Anik Dawre , Effat Sharmin Copyright (c) 2022 Author Sat, 16 Apr 2022 00:00:00 +0000