Asian Journal of Clinical Pediatrics and Neonatology <p><strong class="pull-left">Asian Journal of Clinical Pediatrics and Neonatology (AJCPN)</strong>&nbsp;&nbsp;is an open-access; freely accessible, online and print Quarterly peer-reviewed international journal publishes a wide spectrum of advanced research in different fields of pediatrics and neonatology, covering etiology, diagnosis, therapy and prognosis aspects. <br> <strong>Online ISSN: 2347-3363 | Print ISSN: 2347-3355</strong></p> Society for Health Care & Research Development en-US Asian Journal of Clinical Pediatrics and Neonatology 2347-3355 Comparison of Transcutaneous and Total Serum Bilirubin in Newborns of 34 or More Weeks of Gestation <p><strong>Background: </strong>Measuring the bilirubin concentration with accuracy is essential for diagnosis and proper management of neonatal hyperbilirubinemia. Serum bilirubin (TSB) is considered as the gold standard, but it takes some time.It is painful for the baby and expensive and stressful for the parents. Transcutaneous bilirubin (TcB) can be measured without pain and is very fast.&nbsp; <strong>Aim of the study:</strong> To assess if TcB measurement can be an effective alternate screening test for diagnosing neonatal hyperbilirubinemia. <strong>Subjects and Methods: </strong>A total of 97 newborns with clinical jaundice were enrolled.&nbsp; Before the initiation of phototherapy, venous blood for TSB measurement was drawn. Within 30 minutes Drager’s bilirubinometer JM-103 measured TcB on the infants’ sternum. Simple linear regression analysis determined the relation between TcB and TSB values. The strength of the relationship and agreement between these two methods was calculated by Pearson’s correlation coefficient “r” and Bland-Altmann plot respectively. <strong>Results: </strong>The TcB correlated well with TSB(r=0.95, 95% confidence interval= 0.93 to 0.97). The mean deviation and variability (±2SD) of TcB from TSB were 0.8 and ±2.5mg/dl respectively. There was a good agreement between TcB and TSB. <strong>Conclusion: </strong>Our study showed that TcB checking can be applied as a valuable screening tool in neonates with clinically suspected jaundice.</p> Diptirekha Satapathy Niranjan Mohanty ##submission.copyrightStatement## 2018-09-30 2018-09-30 6 2 1 3 Lamellar Icthyosis: A Clinical Dilemma <p>Congenital Autosomal recessive ichthyosis is a heterogenous group of disorders that are present at birth with generalized involvement of skin and lack of other organ systems. This case report presents involvement of respiratory system and its management with outcome in a rather uncommon presentation of lamellar icthyosis.</p> Amar Verma Rani Manisha R. K. Narayan ##submission.copyrightStatement## 2018-09-30 2018-09-30 6 2 4 6 Etiology of Severe Anemia in Children at a Tertiary Care Hospital. <p><strong>Background: </strong>Public health significance of anemia in children was classified as severe in India. Severe anemia (Hb &lt; 7g/dL) significantly increases the risk of death. Critical diagnostic evaluation and a thorough work-up make the accurate diagnosis of intrinsic red cell abnormalities feasible. Review of etiology helps to formulate strategies to prevent them, and to know the degree of achievement of the targets. Objectives: The aim of the present study was to identify the etiology of severe anemia. <strong>Subjects and Methods: </strong>It is a retrospective record based study done at a tertiary care center. All new severe anemia cases aged 1 month to 18 yrs, which were admitted on Monday from Jan 2017 to Dec 2017 were included. Previously worked up cases coming for transfusions and anemia due to bleeding were excluded. Details of history, physical examination and work-up were obtained for justification of diagnosis based on existing evidence. <strong>Results: </strong>112 children were included. Mean age was 3.94 yrs (+/_3.52) (Range: 1 month-13 years), median and mode were 3 years. Male to female ratio was 1.95:1.&nbsp; 51% of severe anemia cases were due to iron deficiency. 11.6% had confirmed β-Thalassemia Trait (BTT) and 18.75% had suspected Thalassemia Trait (TT). Other causes of severe anemia were: folate deficiency (13.4%), B12 deficiency (1.8%), hereditary spherocytosis (HS) (7.1%), marrow replacement by acute leukemia (6.25%), aplastic anemia&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (2.7%), malaria (2.7%), and antiretroviral therapy induced anemia (0.9%). HS was the second most common cause of hemolytic anemia after thalassemias. <strong>Conclusion: </strong>Though a number of nutrition based initiatives have been initiated in the country, the burden of preventable iron deficiency, contributing to severe anemia cases is enormous, signifying the need for more effective programs to be implemented in India. Folate should be supplemented to all children with anemia irrespective of the cause. Essential workup with proper interpretation of investigations for arriving at diagnosis prior to transfusing the child is obligatory.</p> Suresh Babu Mendu Vedavyasa Srigade ##submission.copyrightStatement## 2018-09-30 2018-09-30 6 2 7 11