Immunotherapy in NORSE- A Case Report

Immunotherapy in NORSE

  • Anjani Bala Junior Resident, Department of Pediatrics, Patna Medical College, Patna, Bihar, India
  • Manoj Kumar Singh Associate Professor, Department of Pediatrics, Patna Medical College, Patna, Bihar, India
  • Abhishek Kumar Senior Resident, Department of Pediatrics, Patna Medical College, Patna, Bihar, India
  • Munish Kumar Assistant Professor, Department of Neurology, Patna Medical College, Patna, Bihar, India
Keywords: Refractory status epilepticus, NORSE, Immunotherapy

Abstract

We present the case of a healthy five-year-old girl who presented with fever followed by refractory status epilepticus. Admitted to the intensive care unit, was managed with intravenous midazolam and first line antiepileptic drugs in loading doses. Seizure continued even then, so other antiepileptic medications were titrated to therapeutic doses. Intravenous acyclovir added in view of possibility of viral encephalitis. She also received high dose intravenous methyl prednisolone. Complete remission of seizure cant be achieved in spite of several antiepileptic drugs. Lastly Intravenous immunoglobulin administered which caused dramatic improvement in clinical condition and complete seizure control. Laboratory investigation including autoimmune and paraneoplastic studies, CSF analysis yielded negative results. MRI brain nothing significant. Our case fulfils the definition of new-onset refractory status epilepticus (NORSE).

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Published
2022-04-16
How to Cite
Anjani Bala, Singh, M. K., Kumar , A., & Kumar , M. (2022). Immunotherapy in NORSE- A Case Report. Asian Journal of Clinical Pediatrics and Neonatology, 10(1), 1-3. Retrieved from https://aijournals.com/index.php/ajcpn/article/view/2284
Issue
Vol 10 No 1 (2022): January - March 2022
Section
Original Article

Copyright (c) 2022 Author

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