Association of Non-alcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease (NAFLD) in Patients of Type 2 Diabetes Mellitus.

Abstract

Background: The most common form of chronic liver disease in children is Non-alcoholic fatty liver disease (NAFLD). It is associated with obesity and a serious public health problem. Non-alcoholic steatohepatitis (NASH) is also commonly associated with type 2 diabetes mellitus (DM). Therefore, this study was carried out to know the Prevalence of NASH and NAFLD in patients of type 2 DM admitted in a tertiary care hospital. Methods: This prospective study enrolled T2DM patients in age group of 25-65 years, attending an outpatient Paediatrics department of University of Lisbon, Lisbon, a tertiary care Centre. NAFLD and NASH will be suspected in a patient who is found to have elevations in liver tests such as alanine aminotransferase (ALT) or aspartate aminotransferase (AST). The only means of proving a confirmatory diagnosis of NASH will be done by liver biopsy. Results: A total of 225 patients, with more number of female patients 80 (55.38%) than male patients 45 (44.61%) were recruited with the suspicion of Nonalcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic steatohepatitis. Out of 225 patients enrolled in the study, n=78 (54.76%) T2DM patients (n=63 female and n=25 male), was identified as having NAFLD, and n=5 as NASH. Conclusion: We conclude that the prevalence of NASH and NAFLD and is high in type 2 DM patients.