Ferritin as a Marker of Severe Dengue in Children

Marker of Severe Dengue

  • Manchala Chandra Sekhar Assistant Professor, Department of Pediatrics, Maheshwara Medical College & Hospital, Patancheru, Medak, Telangana, India.
Keywords: Ferritin level, Dengue fever, convalescent stage

Abstract

Background: The aim is to evaluate ferritin levels in fever caused by dengue virus and their association with the severity of infection with dengue virus in children. Subjects and Methods: It is a Prospective that was done for 1 year in the department of pediatrics. 56 reported cases with a history of dengue fever for clinical evaluation by positive IgG and IgM antibodies and positive NS1 antigen and were included in the sample. All 16-year-old subjects with clinical dengue suspicion presenting in the department of emergency. Results: Out of total of 56 children with mean age of the children were 11.5 years and SD 3.5 years, and 59% were male who were majority. Mean hospital stay duration was 5 3 days. Most of the patients in study discharged in 5-7 days of admission in hospital. The mean serum ferritin levels among cases with DHF were raised than those with DF with significant p-values of< 0.05 on Day 5 and 6 of illness. During Days 5, 6, and 7 after the onset of fever, the results for sensitivity were 83, 86, and 92 per cent respectively. Conclusion: The incidence of hyperferritinaemia in patients infected with dengue virus is suggestive of highly active use of ferritin level in serum is 1,200 ng/ml as a method for predicting progression to DHF starting on Day 4 of the disease and continuing to recover.

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References

Lee LK, Gan VC, Lee VJ, Tan AS, Leo YS, Lye DC. Clinical relevance and discriminatory value of elevated liver aminotransferase levels of Dengue severity. Plos Negl Trop Dis. 2012;6(6):1676. Available from: https://dx.doi.org/10.1371/journal.pntd.0001676.

Published
2020-10-10
How to Cite
Sekhar, M. C. (2020). Ferritin as a Marker of Severe Dengue in Children. Asian Journal of Clinical Pediatrics and Neonatology, 8(3), 7-11. https://doi.org/10.47009/ajcpn.2020.8.3.2
Section
Original Article