Histopathological and Histomorphometric Studies on the Effects of Olanzapine on Vas Deferens and Urinary Bladder: An Experimental Study in Albino Rats.
Effects of Olanzapine on Vas Deferens and Urinary Bladder
Introduction: Olanzapine an atypical anti-psychotic drug is widely used in a number of disorders like schizophrenia and bipolar disorder. Olanzipine shows affinity for a number of muscarinic, dopaminergic and histaminic receptors in the body due to which its effects can be seen on a number of organs in the body. The present study was conducted to see the adverse effects of the drug on the histology of urinary bladder and vas deference as data is not availabe on these organs. Subjects and Methods: Twelve male albino rats divided into equal number of experimental and control groups i.e. 6 rats each. Olanzapine was injected intraperitoneally in experimental rats at a dose of 4mg/kg for 6 weeks daily. Results: Control group received same volume of normal saline, daily, intraperitoneally for the same period. Conclusion: Histopathological and histomorphometric changes conformed degeneration in urinary bladder & vas deferens.