Evaluation of insulin resistance in young obese and its relation with smoking

Abstract

Aim: To assess insulin resistance in young obese and its relation with smoking. Methodology: Ninety healthy subjects of either gender was divided into two groups of 45 each. Group I were smokers and group II were non-smokers. The mean weight (kgs), height (cm) and BMI (kg/ m2) was calculated. Serum insulin was estimated by sandwich ELISA technique. Insulin resistance was calculated by the formula- [HOMA-IR = FBG (mmol/L) 9 FPI (mIU/ml)/22.5. The results were compiled and subjected for statistical analysis using Mann Whitney U test. P value less than 0.05 was set significant. Results: Group I had 25 males and 20 females and group II had 22 males and 23 females. There were 35 normal in group I and 23 in group II, 6 overweight in group I and 12 in group II and 4 obese in group I and 10 in group II. The difference was significant (P< 0.05). The mean HOMA-IR Index in group I was 1.84 and in group II was 1.60. The difference was non- significant (P> 0.05). Conclusion: Young smokers with obesity were prone to develop insulin resistance. Smokers can be counselled that discontinuation of smoking especially in early stages could bring substantial reversal of the damage caused and hence this is a strong motivating factor for smokers to discontinue early.