Asian Journal of Medical Research

Chandipura Virus: A Deadly Unknown Virus

2024-08-14T05:17:01+00:00

Chandipura virus (CHPV) is a member of the Rhabdoviridae family under the Vesiculovirus genus which poses a significant public health threat primarily in Asia. It was discovered during an outbreak in Maharashtra, India in 1965. CHPV is transmitted by sandflies of the Phlebotomus genus, affecting predominantly children with acute encephalitis syndrome (AES). Clinical manifestations include fever, seizures and neurological complications, often leading to high mortality rates. The management focuses on early detection, supportive care, and vector control strategies. Further research is needed to enhance understanding, vaccine development and effective public health interventions against this emerging pathogen.

Naegleria Fowleri "The Brain -Eating Amoeba": A Review

2024-08-14T05:19:26+00:00

Naegleria fowleri is a free-living amoeba (FLA) that is commonly known as the “brain-eating amoeba.” This parasite can invade the central nervous system (CNS), causing an acute and fulminating infection known as primary amoebic meningoencephalitis (PAM). Even though PAM is characterized by low morbidity, it has shown a mortality rate of 98%, usually causing death in less than two weeks after the initial exposure. This review summarizes the most recent information about N. fowleri, its pathogenic molecular mechanisms, and the neuropathological processes implicated. Additionally, this review includes the main therapeutic strategies including the possible use of immunomodulatory agents to decrease neurological damage.