Assessment of Lipid Profile and CRP Level in DM Patients

Lipid Profile and CRP Level in DM Patients

Abstract

Background: To assess lipid profile and CRP level in diabetes mellitus patients. Subjects and Methods: Fifty- eight type II diabetes mellitus patients were selected and anthropometric measurements such as body weight (kg), height (m), waist circumference (cm), and hip circumference (cm), were recorded. Body mass index and waist: hip ratios were calculated. 12 hour fasting venous blood samples were collected and serum hs-CRP, serum cholesterol serum TGs, and high-density lipoprotein (HDL) levels were measured. Results: Group I had 30 males and 28 females and group II had 24 males and 34 females. The mean age in group I was 37.2 years and in group II was 38.5 years. The mean weight was 65.2 kg in group I and 63.4 kg in group II, height was 1.78 meters in group I and 1.65 meters in group II, BMI was 22.4 Kg/m2 in group I and 21.5 Kg/m2 in group II. Waist circumference was 80.2 cm in group I and 76.5 cm in group II, hip circumference was 96.3 in group I and 95.5 in group II, W/H ratio was 0.81 in group I and 0.78 in group II. The difference was significant (P< 0.05). The mean hs- CRP was 2.7 mg/dl in group I and 1.5 mg/dl in group II, TG was 178.2 mg/dl in group I and 135.3 mg/dl in group II, TC was 180.4 mg/dl and 150.2 mg/dl in group II, HDL was 37.2 mg/dl and 54.3 mg/dl in group II, LDL was 106.2 mg/dl in group I and 74.4 mg/dl in group II and VLDL was 35.5 mg/dl in group I and 27.1 mg/dl in group II. The difference was significant (P< 0.05). There was positive correlation of hs-CRP with TG (r- 0.23, p< 0.05), TC (r-0.45, p< 0.05), LDL (r-0.49, p< 0.05) and VLDL (r- 0.27, p< 0.05) and negative correlation of HDL (r- -0.23, p< 0.05). Conclusion: There was increased level of high-sensitivity C-reactive protein and alteration of lipid profile in type II diabetes mellitus patients.