Assessment of Relationship between Serum 25 (OH) Vitamin D and Insulin Resistance in Prediabetes:

K Dhananjay; Surendra Nehru M; Srinivas  Naik

K Dhananjay Associate Professor, Department of Medicine, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
Surendra Nehru M Associate Professor, Department of Medicine, Nimra Institute of Medical Sciences, Andhra Pradesh, India
Srinivas Naik Associate Professor, Department of Medicine, Fatima Institute of Medical Sciences, Kadapa, India

Keywords: prediabetes, insulin resistance, hypovitaminosis-D, hyperglycemia

Abstract

Background: To evaluate relationship between serum 25 (OH) vitamin D and insulin resistance in prediabetes. Subjects and Methods: We enrolled fifty diabetics, forty pre-diabetes and thirty- five healthy control individuals. In all, waist circumference (WC), hip circumference (HC), waist- hip ratio, HbA1C and lipid profile such as LDL- C, HDL- C and triglyceride was recorded. Serum insulin, HOMA2-IR and HOMA2-β was estimated. Statistical inferences using chi- square test was used. Results: Maximum pre- diabetes subjects (15) had serum 25 (OH) D >30 ng/ml, diabetes (16) between 21-30 ng/ml and control (13) >30 ng/ml. 1 hour PG blood glucose had statistically significant positive correlation with FBS and 2 hours PG blood glucose (P< 0.05). Conclusion: Vitamin-D deficiency led to worsening of insulin resistance in individuals with prediabetes.

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Assessment of Relationship between Serum 25 (OH) Vitamin D and Insulin Resistance in Prediabetes

Relationship between Serum 25 (OH) Vitamin D and Insulin Resistance in Prediabetes

Abstract

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