A Comparative Study Of Efficacy Of 10% KOH, 50% Trichloroacetic Acid And 25% Podophyllin For The Treatment Of Genital Molluscum In Females
Treatment Of Genital Molluscum In Females
Background: Molluscum contagiosum is caused by MC virus, the largest human virus and sole member of genus molluscipox. Transmission of the virus occurs by direct person-to-person contact or via contact with infected objects. Sexually active adults are more prone to develop it in genital area due to sexual transmission. Subjects and Methods: A randomized comparative therapeutic study was conducted from November 2017 to October 2018. Results: A total of 60 female patients with genital molluscum were enrolled in the study. The average age of the patients was 25.6 yrs. 66% presented less than 10 lesions, 28% presented from 10 to 20 lesions, and 6% presented more than 20 lesions at the initial examination. The results showed that the mean lesion count decreased from 22.39 to 6.75 with KOH, from 20.79 to 4.31 with TCA and from 20.49 to 4.1 with 25% podophyllin at the end of 4 weeks. We found complete clearance of lesions in 13 (65%) patients with 10% KOH, 15 (75%) patients with TCA, and in 11 (55%) patients with 25% podophyllin. Minor side effects were seen in 11 (55%) patients on TCA, 12 (60%) patients on KOH and 16 (80%) patients on podophyllin. Conclusion: All the three modalities i.e. 10% KOH, 50% TCA and 25% podophyllin are effective local therapies for the treatment of genital molluscum.