A Prospective Study to Assess the Bone Marrow Aspiration for Findings of Patients with Hematological Disorders
Study to Assess the Bone Marrow Aspiration
Background: Examination of bone marrow is beneficial procedure for the diagnosis of hematological and non-hematological diseases. Bone marrow aspiration singly is usually sufficive for the diagnosis of nutritional anemia, majority of the acute leukemia and Immune thrombocytic disorders. The present study was conducted with the aim to assess the bone marrow aspiration findings amongst subjects with hematological disorders. Subjects and Methods: The present cross sectional study was conducted in the department of pathology, Government Medical College, Dungarpur, Rajasthan (India) during a period of 2 years. Amongst all the subjects, peripheral smears, reticulocyte counts, sickling test and hemogram were obtained. Special stains Periodic acid Schiff staining was done for all subjects with acute lymphocytic leukemia, acute myeloid leukemia and Gaucher’s disorder. Block positivity was shown amongst ALL cases. In subjects with Gaucher’s disorder, Gaucher cells showed wrinkled tissue paper appearance using PAS staining. All the data thus obtained was arranged in a tabulated form and analyzed using SPSS software. Percentage of all the data was obtained. Results: The present study bone marrow aspiration was performed amongst 110 subjects and bone marrow biopsy was performed amongst 54 subjects. There were 48.2% cases of anemia, 14.5% (n=16) cases of acute leukemia. In 10.9% of cases myeloproliferative disorders were observed and 1.8% cases had myelodysplastic syndrome. There were 20.4% cases of hyoplastic anemia. There were 11.1% subjects that showed normal results. NHL deposits and myelofibrosis was seen in 5.6% cases each. ALL was diagnosed in 1 case. Conclusion: Aspiration of bone marrow is important for diagnosing, determining the prognosis and therapeutic response of different types of hematological and non hematological conditions.