Correlation between Gleason Score and Bone Scintigraphy Results in Metastatic Prostate Cancer, the Silent Marauder: Whether a Fact or a Fictitious Scenario??

Correlation between Gleason Score and Bone Scintigraphy

Abstract

Background: Aim & objective: To interpret the association between gleason score and bone scintigraphy results in patients with metastatic prostate cancer.  Subjects and Methods: A five years retrospective study (January 2013 to December 2017) of patients with diagnosis of locally advanced & metastatic prostatic adenocarcinoma at Institute of Nephro-Urology, Bangalore was carried to collect information about prostate volume, serum PSA, Gleason score and bone isotope scan results. Statistical analysis was performed using Chi-square test, Fisher exact test and students unpaired t test to analyse the association between these clinical, pathological and radiological parameters and a value of <0.05 was considered statistically significant. Results: Mean (SD) patient age was 68.96 (7.56) years. Both serum PSA levels and prostate volume showed statistically significant association (P<0.001) with gleason score/ISUP grade and positive bone scan results but Gleason score was not found have significant association (P=0.78) with bone metastasis. Conclusion: Although high grade prostatic carcinomas [GS ? 7 (4+3)] are known to have high plausibility of bone metastasis, we did not see such association in our study , hence high Gleason score was not a predictor for bone metastasis always & we conclude it as a fictitious scenario to be looked upon with utmost importance.