Evaluation of Histopathogical Changes in Gallbladder Mucosa in Gallbladder Stone Patients: An Institutional Based Prospective Study

Histopathogical Changes in Gallbladder Mucosa in Gallbladder Stone Patients

Abstract

Background: Mucus, calcium   and lipids act  together  and lead to the formation of  the gallstones. Gallbladder and biliary tract epithelium is unprotected from the high concentrations of  harmful compounds both exogenous and endogenous that are excreted into the primary bile. The present study was conducted with the aim to evaluate the histopathogical Changes in Gallbladder Mucosa in Gallbladder Stone Patients. Subjects and Methods: The present retrospective study was conducted in the Department of Pathology, JLN Medical College, Ajmer, Rajasthan, India. For histopathological examination, Gall bladder was sectioned from neck to fundus and carefully washed with 0.15 N saline. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Percentage of the whole data was calculated. Results: There were a combination of alterations observed in single bladder, some part was normal while the other showed signs of hyperplasia. Normal epithelium was seen in 20% cases, there were 44.7% cases that showed epithelial hyperplasia. Conclusion: Pathological alteration on the epithelium of gall bladder plays a pivotal role in the gall stone formation and if unmanaged or untreated it can lead to dysplastic changes and ultimately carcinoma in situ.