An Epidemiological study and analysis of prognostic factors of testicular carcinoma

Testicular Carcinoma

Abstract

Background: Testicular carcinoma is an uncommon malignancy overall accounting for 12% of all tumours in men, testicular cancer is the most common malignancy in young men. The aim of the study was to analysis of prognostic factor of testicular carcinoma and determines their epidemiologic features, in order to provide a guideline for clinical treatment and follow ups. Subjects and Methods: Patient clinical data, including age, tumor position, pathological type, clinical stage, AFP, HCG and LDH levels, as well as postoperative treatment methods were identified and classified. Subsequently, the patients' conditions during the follow-up period following surgery were recorded. The survival rate was also calculated and prognosis was analyzed. Age upon operation, laterality of tumor, pathologic diagnosis, and preoperative serum AFP levels were reviewed. In GCT cases, preoperative serum AFP levels were analyzed to predict malignancy in different age groups. P<0.05 was considered to indicate a statistically significant difference. Results: A total of 195 cases with testicular carcinoma were enrolled in this study. In 62.6% cases tumors were located on the right side, and in (37.4%) tumors were located on the left side. The relation between the testicular seminoma and pathological Types shows that out of the 195 cases, 121(62.05%) cases were confirmed with typicaltesticular seminoma, 52(26.7%) cases with testicular seminoma combined with embryonal carcinoma and 22(11.3%) cases withtesticular seminoma combined with embryonal carcinoma and teratoma. Conclusion: We concluded that the pathological types should be confirmed to determine the postoperative adjunctive treatment method and improve the postoperative survival rate. Epidemiological features of TC show a persistent lack of the knowledge about the symptoms of TC in the general population, in spite of extended health education.