Study on Association between HbA1c and Lipid profile in Type 2 Diabetic Patients: A Teaching Hospital Based Study:

Pallavi Anand; Niranjan Shah; Dr Shrawan; Uday Narayan Singh; P. atayanarayana

doi:10.21276/ajmr.2019.8.1.BC6

Pallavi Anand Associate professor, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Rama City, Mandhana, Kanpur, Uttar Pradesh 209217.
Niranjan Shah Ph.D. Scholar, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Rama City, Mandhana, Kanpur, Uttar Pradesh 209217.
Dr Shrawan Professor, Department of Medicine, Rama Medical College Hospital and Research Centre, Rama City, Mandhana, Kanpur, Uttar Pradesh 209217.
Uday Narayan Singh Professor & Head, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Rama City, Mandhana, Kanpur, Uttar Pradesh 209217.
P. atayanarayana Professor and Dean, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Rama City, Mandhana, Kanpur, Uttar Pradesh 209217.

DOI: https://doi.org/10.21276/ajmr.2019.8.1.BC6

Keywords: Type-2 DM, FBS, HbA1c and Lipid parameters

Abstract

Background: Diabetes mellitus is characterized by chronic hyperglycaemia with disturbances in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. Subjects and Methods: type 2 diabetic patients (Age range of 25-70 years) with an age & sex matched along with 50 healthy controls were selected as per the inclusion and exclusion criteria. Results: The mean age (Mean SD) of cases and controls were 48.613.42 and 30.910.23 years and mean BMI 21.384.2 & 25.21.83 respectively [Table-1]. The Mean SD of cases and controls were FBS (134.62 20.2), HbA1c (7.8 2.42), TC (155.631.7), TG (152.326.04), HDL-C (43.4 8.07) and LDL-C (81.78 36.8) and FBS (104 12.06), HbA1c (5.1 1.4), TC (142.62.5), TG (112.520.3), HDL-C (49.6 9.5) and LDL-C (104.06 17.15) respectively[Table-1]. In this study, the level of FBS, HbA1c, TC, TG, LDL-c, were significantly increased (P<0.05) while HDL-c level was significantly decreased (P<0.05) as compare to controls. Conclusion: HbA1c showed positive correlation with TC, TG, & LDL-c and negative correlations were observed between HbA1C and HDL-c.

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