Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) as Predictor of Pre-diabetes in Non-Alcoholic Fatty Liver Disease (NAFLD)
Predictor of Pre-diabetes in Non-Alcoholic Fatty Liver Disease
Background: India is the diabetes capital of the world with every fifth diabetic in the world is an Indian. Subjects and Methods: We studied Sixty non-alcoholic, non-diabetic, normotensive obese NAFLD subjects with WHR:>0.9 in males and >0.85 for females according to inclusion and exclusion criteria. Results: NAFLD, a chronic condition ranging from benign steatosis, (i.e., hepatic triglyceride accumulation >5.5% using magnetic resonance imaging or >5% corresponding to 50 mg/g by wet weight), to more significant liver injury, i.e.,non-alcoholic steato-hepatitis(NASH).Conclusion: Association of NAFLD with features of insulin resistance and was more prevalent among subjects with IGT. The increased risk for cardio-metabolic diseases in NAFLD might be due to hepatic overproduction of glucose, VLDL, inflammatory factors as a result of insulin resistance.