Comparison between intravenous sodium valproate and sodium phenytoin as second line treatment of status epilepticus in children

Intravenous sodium valproate and sodium phenytoin as second line treatment of status epilepticus

Abstract

Background: Status epilepticus (SE) is one of the most significant neurological emergencies. It was previously defined as multiple seizures without recovery and regaining consciousness between intervals lasting for more than 30 min. Subjects and Methods: This study conducted in the Department of Pediatrics in the tertiary care centre. The duration of the study was over a period of six month. Results: Two groups were taken in this study, one is group P and another one group V .Group P was received sodium valproate and group V received phenytoin sodium intravenously as second line treatment.  Sixty cases were involved in each group. Out of 60, 53.3% male & 46.7% female were found in Group P. Whereas, 60% male & 40% female were found in Group V .In the both group most prevalent age was 11-12 year followed by other age group. Conclusion: It was found to be safer also than phenytoin in terms of respiratory depression. But more studies are required to compare the ef?cacy of these two AEDs in the pediatric population.