Human Peripheral Nerve Regeneration Using Stem Cells

Muhammad Zubair Yousaf; Sajjad Ali Shah; Anwar Saeed; Khalid Mahmood Anjum; Muttiurrehman Khan

Muhammad Zubair Yousaf Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, China
Sajjad Ali Shah University of Malakand, Malakand, Pakistan
Anwar Saeed University of Malakand, Malakand, Pakistan
Khalid Mahmood Anjum University of Veterinary and Animal Sciences, Lahore, Pakistan.
Muttiurrehman Khan University of Veterinary and Animal Sciences, Lahore, Pakistan.

Keywords: Peripheral nervous system (PNS), Stem cells, Schwann cells, Neurotropic factors

Abstract

Peripheral nervous system (PNS) is the most important system of the body that controls a wide range of organs and
functions. When accidentally injured, PNS has long term consequences. Despite of the various surgical treatments, fully
functional recovery is impossible and often results in some deficiency. Recent advances in stem cell technology have enabled
to recover the full functional peripheral nervous injuries. Different stem cells have the potential to differentiate into
Schwann Cells. Schwann cells have great importance in peripheral nerve regeneration because it provides a good media for
axon migration and also important in the release of neurotrophic factors which enhances nerve growth. Use of autologous
stem cells reduces immunogenic reactions. Nerve regeneration using the different types of stem cells has been briefly
discussed in this review.

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