To Examine the Amendment in Desire Following High Frequency rTMS Stimulation of the Correct Dorsolateral Anteriorcortex (DLPFC) in Patients with Opioid Dependence as Compared to Sham Stimulation: A Comparative Hospital Based Study:

Daljeet Singh Ranawat; Bhanu Pratap Singh; Christoday RJ Khess; Abhimanyu Singh; Neeti Mahala; Mukesh Choudhary

Daljeet Singh Ranawat Senior Resident, Department of Psychiatry, Government Medical College and Bangar Hospital, Pali, Rajasthan, India.
Bhanu Pratap Singh Senior Resident, Department of Psychiatry, Government Medical College and Bangar Hospital, Pali, Rajasthan, India.
Christoday RJ Khess Director Professor of Psychiatry & I/C Center of Addiction Psychiatry, CIP, Kanke, Ranchi, Jharkhand, India.
Abhimanyu Singh PG Resident, Department of Medicine, DY Patil Medical University, Kolhapur, Maharastra, India.
Neeti Mahala PG Resident, Department of Obs and Gynaec, Mahatma Gandhi Medical College And Hospital, Jaipur, Rajasthan, India.
Mukesh Choudhary PG Resident, Department of Anaesthesia & Analgesia, J.L.N. Medical College, Ajmer, Rajasthan, India.

Keywords: Opiod Abuse, rTMS, DLPFC, ASI

Abstract

Background: Opioid abuse is a worldwide problem causing serious physical, psychological, social and economic consequences. The aim of this study to assess the change in craving parameters following high frequency rTMS stimulation of the right DLPFC in patients with opioid dependence as compared to sham stimulation. Subjects and Methods: This is a prospective, hospital-based, randomized, sham-controlled transcranial magnetic stimulation study conducted at the Centre of Cognitive Neurosciences Department of Central Institute of Psychiatry (C.I.P.), Ranchi, India. The hospital has bed strength of 673 with more than 53,500 patients attending the outpatient clinic every year. The data was analyzed using the computer software program, Statistical Package for Social Sciences-version 10.0 (SPSS-10.0) for Windows, with different parametric and nonparametric tests, as indicated. The level of significance was taken as p < 0.05 (two tailed). Results: Our study showed that the socio demographic and clinical variables (categorical) between the active and sham groups. Also there was no significant difference in type of opiates and family psychiatric history between the two groups. There was positive correlation between persistence and OCDUS with significant (p<.05) in one week & TCI dimension with OCDUS with significant (p<.05) at 4 weeks. There was no significant correlation between ASI and OCDUS with significant (p<.05). Conclusion: We concluded that neurophysiological variables such as quantitative EEG, evoked potentials, frontal activation tasks should be measured along with rTMS in opioid dependence for more comprehensive assessment of the treatment effect.

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