To Examine the Amendment in Desire Following High Frequency rTMS Stimulation of the Correct Dorsolateral Anteriorcortex (DLPFC) in Patients with Opioid Dependence as Compared to Sham Stimulation: A Comparative Hospital Based Study
Opioid Dependence as Compared to Sham Stimulation
Background: Opioid abuse is a worldwide problem causing serious physical, psychological, social and economic consequences. The aim of this study to assess the change in craving parameters following high frequency rTMS stimulation of the right DLPFC in patients with opioid dependence as compared to sham stimulation. Subjects and Methods: This is a prospective, hospital-based, randomized, sham-controlled transcranial magnetic stimulation study conducted at the Centre of Cognitive Neurosciences Department of Central Institute of Psychiatry (C.I.P.), Ranchi, India. The hospital has bed strength of 673 with more than 53,500 patients attending the outpatient clinic every year. The data was analyzed using the computer software program, Statistical Package for Social Sciences-version 10.0 (SPSS-10.0) for Windows®, with different parametric and nonparametric tests, as indicated. The level of significance was taken as p < 0.05 (two tailed). Results: Our study showed that the socio demographic and clinical variables (categorical) between the active and sham groups. Also there was no significant difference in type of opiates and family psychiatric history between the two groups. There was positive correlation between persistence and OCDUS with significant (p<.05) in one week & TCI dimension with OCDUS with significant (p<.05) at 4 weeks. There was no significant correlation between ASI and OCDUS with significant (p<.05). Conclusion: We concluded that neurophysiological variables such as quantitative EEG, evoked potentials, frontal activation tasks should be measured along with rTMS in opioid dependence for more comprehensive assessment of the treatment effect.