Evaluation of Serum Leptin Level and BMI in Diabetic Patients: An Institutional Based Study
Evaluation of Serum Leptin Level and BMI in Diabetic Patients
Background: Diabetes mellitus is one of the major public health problems these days. Diabetes is a metabolic diseases characterized by hyperglycemia. Micro vascular and macrovascular complications of diabetes mellitus are very common. Leptin is a protein which is released from adipose tissue. Leptin can have a significant role in pathogenesis of diabetes. Aim: The objective of this study was to evaluate the variation in serum leptin levels in type 2 diabetes mellitus and control group. Subjects and Methods: The study group consisted of 100 patients. 50 patients of type 2 DM and 50 normal healthy controls were selected for the study. Blood glucose (FBS and PPBS), HbA1c, Serum lipids and lipoproteins, Serum leptin, and Body mass index (BMI) were estimated type 2 DM patients and normal healthy controls. Results: In group 1 (healthy individuals), BMI was 23.6± 2.1 and in group 2 (type 2 DM patients), it was found to be 26.1 ± 2.1. A statistically significant difference was observed in BMI of both groups. Serum leptin level in group 1 was found to be 5.42±2.22 and in group 2 it was found to be 9.22± 1.82. A highly significant difference was observed in leptin level in both groups p<0.0001. Conclusion: We concluded that serum leptin levels are higher in patients suffering from Type 2 diabetes mellitus and it is strongly correlated positively with BMI.