Comparative Evaluation of Serum Lipid Profile in Leukoplakia and oral Cancer – A Teritiary Referral Hospital Based Study

Serum Lipid Profile in Leukoplakia and oral Cancer

Abstract

Background: Context: Oral cancer is one of the major cause of morbidity and mortality worldwide. Lipids have a major role in maintaining the cell integrity. Studies showed that individuals with lower serum lipid levels were having an increased risk of cancer. Aim: To evaluate and compare the variation in serum lipid profile levels in normal patients, patients with leukoplakia and oral cancer. Subjects and Methods: This Study comprised of a total 90 patients, 30 with oral cancer, 30 with leukoplakia and 30 age and sex matched normal controls. Serum lipid profile was estimated in all 90 patients by a semi-autoanalyzer. Results: In comparison to controls, oral cancer patients had significantly lower levels of Total Cholesterol (TC), High Density Lipoproteins (HDL) and Very Low Density Lipoproteins (VLDL). TC, HDL, and VLDL were also lower in leukoplakia group compared to that of controls, but the difference was insignificant. Conclusion: There is a significant relationship between low serum lipid profile and oral cancer and hence alterations in lipid profiles may have a pivotal role in predicting oral cancer.