Is Thyroid dysfunction affecting Oxidative Stress Index in Semen

Abstract

Background: Declining trend of semen quality has become a major public health problem. Oxidative stress is playing major role in the current scenario of poor male fertility potential. Thyroid hormones have a pivotal role to play in that context as it potentially alters the oxidative status of the semen. Thus, in present study effect of thyroid abnormalities on oxidative status of semen quality is explored. Objective: This study aimed to determine the relationship between Thyroid dysfunction and Oxidative stress in semen of infertile couple. Subjects and Methods: The study included 100 Semen samples from the males of infertile couple attending the infertility clinic JNMCH AMU in the year 2016-2018. TSH levels were determined and simultaneously Total Antioxidant Capacity and Oxidative stress status of semen samples was evaluated by colorimetric method. The effect of thyroid dysfunction on Oxidative stress of semen was assessed using Pearson moment correlation test. Results and Conclusion: Higher values of TSH caused significant reduction in TAC and elevation of oxidative stress Index. Thereby showing that Thyroid dysfunction adversely affects the oxidative status and compromises male reproductive function.