Assessment of Serum Creatinine and Cystatin C as a Significance of Nephropathy in Diabetic Patients

Abstract

Introduction: To assess serum creatinine and cystatin C as a significance of nephropathy in diabetic patients. Subjects and Methods: Eighty diabetes patients and eighty healthy controls were selected and divided into 2 groups. The level of lipid peroxidation was determined by examination of malondialdehyde (MDA) using a modified method. Cystatin C and serum creatinine levels were measured. Results: Group I had 45 males and 35 females and group II had 40 males and 40 females. The mean MDA level in group I was 4.06 M and in group II was 1.32 M. Creatinine level was 0.95 mg/L in group I and 0.84 mg/L n group II and mean cystatin was 0.82 mg/L in group I and 0.89 mg/L in group II. The difference was significant (P< 0.05). Conclusion: There was increased level of MDA in diabetic as compared to non- diabetics.