Antibody Response Against Covid-19 Among Vaccinated Health Care Workers – A Cross-Sectional Serosurveillance Study
Antibody Response Against Covid-19 Among Vaccinated Health Care Workers
Background: The vaccination drive against COVID-19 in India began on January 16th, 2021, with two approved vaccines - CovishieldTM and CovaxinTM. Despite hurdles in the production and supply of vaccines, the vaccination rollout envisaged the successful vaccination of the entire adult population of the country by the end of this year. The humoral response against COVID-19 induced by the administration of two doses of any one of the two available vaccines was estimated among health care workers (HCW). Subjects and Methods: Semiquantitative estimation of SARS-CoV-2 IgG antibody against S1 domain of spike protein was done in the serum obtained from 89 HCWs using ELISA. The antibody response was correlated with age, sex, body mass index (BMI), and co-morbid conditions. A comparison of antibody response was done among the infection naïve and naturally infected study population. The common adverse effects following vaccination were identified. Results: The seropositivity rate of this study was 86.5%. Covishield recipients reported higher seropositivity (89%). There was no significant correlation of antibody response with age, sex, BMI, and co-morbid conditions. The antibody response was significantly higher in participants who had previous COVID infection when compared with the infection naïve group. Conclusion: Vaccination is essential for containing the current pandemic. Significant antibody titer is present in vaccinated individuals. The immune response of participants who had been previously infected is significantly improved with vaccination.
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