Study to Compare the E?ect of Oral Gabapentin with Oral Clonidine for Perioperative Analgesia and its E?ect on Prevention of PONV

Perioperative Analgesia and its Effect on Prevention of PONV

Abstract

Background: Ideal pre-medicant would be that, which can decrease preoperative anxiety of the patients, can effectively attenuate the hemody- namic stress response to laryngoscopy and intubation and also provide post-operative analgesia with easy availability and minimal side effects. Subjects and Methods: The study was conducted in fifty adult patients for laparoscopic cholecystectomy under general anaesthesia. The patients were randomly allocated into two groups of 25 each, Group-I Gabapentin group, received oral tablet Gabapentin (300 mg) andGroup-II Clonidine group received oral tablet Clonidine(2gm), 2 hours before surgery. The post operative variables studied were heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, VAS score, mean consumption of rescue analgesic, mean consumption of Ondansetron for post operative nausea and vomiting. Results: There was no statistically significant difference between the two groups in respect of HR, SBP, DBP, and MAP. There was significant difference in the VAS score between the 2 groups; lower scores in the Gabapentin group. There is statistically significant difference in mean consumption of opioids in Gabapentingroup was (4 13.84mg) with P value 0.0108and as well as mean Ondansetron consumption for PONV in Gabapentin group (0.16 0.78 mg) with P =0.0089. Conclusion: Both the drugs have similar effect over the intraoperative hemodynamics and promising role in maintenance of perioperative analgesia. Both drugs have a promising role in postoperative analgesia, though Gabapentin is found to have better analgesia compared to clonidine. Gabapentin has better effect on the control over PONV compared to Clonidine.