E?ect of Vaginally Administered Glyceryl Trinitrate Placebo on Cervical Ripening Prior to Induction of Labor in Overdue Pregnancies
Vaginally Administered Glyceryl Trinitrate Placebo on Cervical Ripening
Abstract
Background: The aim is to assess effect of vaginally administered glyceryl trinitrate placebo on cervical ripening prior to induction of labor  in overdue pregnancies. Subjects and Methods: Eighty pregnancies were divided into 2 equal groups of 40. Group I women received vaginal suppositories-containing GTN inserted in posterior fornix and group II women received placebo. We prepared placebo and GTN involving vaginal ovules in the department of Pharmacy. All vital parameters such as blood pressure, heart rate, fetal heart rate and temperature was measured for 1 hour. Results: The mean age in group I was 27.2 years and in group II was 26.5 years. The mean body weight was 68.4 kgs in group I and 65.9 kgs in group II. Height found to be 1.56 meters in group I and 1.57 meters in group II. The mean BMI was 28.1 kg/m2 in group I and 27.7 in group II. Parity was 0.87 in group I and 0.94 in group II. Gravida was 2.45 in group I and 2.26 in group II. The mean Bishop score before, at 3rd hour, 6th hour and 12th hour recorded was 3.59, 4.45, 5.46 and 6.68 in group I and 3.56, 4.27, 5.04 and 6.42 in group II. Time period upto delivery (hours) was 5.42 and 18.5, period between drug administration and amniotomy (hours) was 9.24 and 10.6, period between drug administration and initiation of oxytocin (hours) was 10.8 and 12.1 and period between drug administration and active phase (hours) was 9.4 and 11.2 in group I and II respectively. Delivery was normal spontaneous delivery seen in 34 in group I and 30 in group II and caesarean section 6 in group I and 10 in group II. Adverse events found to be postpartum bleeding seen in 5 in group I and 4 in group II, uterine tachysystole in 3 in group I and 4 in group II and fetal distress 3 in group I and 1 in group II. The difference was non- significant (P> 0.05). Conclusion: There was no additional benefits of administration of Glyceryl trinitrate in posterior fornix in in cervical ripening in women with overdue pregnancies.
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