Study the status of oxidative stress markers and trace elements related to the antioxidative system in type 2 diabetes.

Abstract

Objective:Study the status of oxidative stress markers and trace elements related to the antioxidative system in type 2 diabetes Methods:70 Diabetic patients of age more than 30 years and 40 age and sex matched healthy nondiabetic individuals were included .Cases were divided in to two groups (1).Diabetic with microvascular or macrovascular complication (2). Diabetic without complication . Malondialdehyde, Zinc, Copper ,magnesium and level of selenium was assayed by using appropriate reagents. Results:In DWC study group 21(65%) patients had microalbuminuria and 11 (34%) patients had macroalbuminuria. Mean serum MDA level in age/sex matched healthy controls were 1.87 0.52 mmol/L, while in DWC group it was 2.660.54 mmol/L (p=0.001). Mean serum level of all trace elements (selenium, zinc, copper and magnesium) were statistically significantly (p-value<0.001) lower in diabetic patients with complications group, as compared to age/sex matched healthy controls .Mean serum MDA level in diabetic patients without complications were elevated (p=0.001). Mean serum level of selenium, zinc, copper and magnesium were statistically significantly (p<0.001) lower in diabetic patients without complications group, as compared to age/sex matched healthy control . Conclusion:This study showed that there is a definite role of these trace elements in oxidative stress in the pathogenesis and complications of diabetes. In order to better understand, further clinical studies are required enrolling larger number of patients and using more sophisticated techniques , so that antioxidants and mineral supplementation will be used for better management of diabetic patients.