Efficacy of Single Dose versus Multiple Dose of Pre-Operative Antibiotic: Teaching Hospital Based Study

Efficacy of Single Dose versus Multiple Dose of Pre-Operative Antibiotic

  • Kamta Prasad Gupta Assistant Professor, Department of Surgery, Varun Arjun Medical College & Rohilkhand Hospital, Banthra, Shahjahanpur, India https://orcid.org/0000-0002-8563-7937
  • Dinesh Pratap Singh Associate Professor, Department of Surgery, Varun Arjun Medical College & Rohilkhand Hospital, Banthra, Shahjahanpur, India
Keywords: Single dose, multiple dose and Antibiotic


Background: The major crisis in any type of surgery is understood to be Surgical Site Infection (SSI). Although laparoscopic cholecystectomy is a nominally invasive procedure, there is a dominant prevalence of SSI in patients. It is also believed that prophylactic antibiotic has major impact in reducing SSI. Subjects & Methods: Seventy cases were enrolled in this study with knowledgeable consent. The study was carried out over a time period of ten months. The subjects acknowledge for elective laparoscopic cholecystectomy were incorporated in our study. Results: Out of the 70 randomized patients, 35 were allotted in single dose (SD group) while 35 patients were allotted in multiple doses (MD group), who got planned treatments and were then investigated. Of the 70 patients, female patients were 58(82.9%) and males were 12(17.1%). Total 43.62 12.18 years was the mean age of patients having symptomatic cholelithiasis, with 18 years as minimum and 77 years as maximum age. The peak of disease was documented in the age group of 30 to 39 years (28.6%). Conclusion: Utility of single antibiotic dose before anesthesia induction in laparoscopic cholecystectomy was likewise efficient as the use of multiple antibiotics doses in surgical site infection of postoperative periods.


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