Haemodynamic Stability and Side Effects of Granisetron and Granisetron Dexamethasone Combination

Haemodynamic Stability and Side Effects of Granisetron and Granisetron Dexamethasone Combination

  • Asha Rani BN Assistant professor, Department of Anesthesia, Sanjay Gandhi Institute of Trauma and Orthopedics, Bangalore, Karnataka
  • Swati Bhatt Professor, Department of Anesthesia, Baroda Medical College, Vadodara

Abstract

Background: Granisetron is a selective 5-hydroxy tryptamine -3(5HT3) receptor antagonist with little or no affinity for other serotonin receptors. Chemically, it is endo-N-(9-Methyl-9-Azabicyclo [3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride. Serotonin receptors of the 5HT3 type are located peripherally on vagal nerve terminals and centrally in the CTZ of the area postrema. Subjects and Methods: The protocol was explained to patients and informed consent was taken. All the patients received tab. Diazepam (10mg) and tab. Ranitidine (150mg) on the previous night before surgery. Patients were kept nil by mouth for 8 hours before surgery. On the day of surgery, nil by mouth status of patient was confirmed and written and informed consent obtained. Intravenous line was secured with crystalloid infusion was started. Results: In Group-GD, 2 patients had Headache, 1 patient had dizziness and 2 patients had dry mouth, while in Group-G, 3 patients had Headache, 1 patient had dizziness and 2 patients had dry mouth which did not require any treatment. No other side effect was observed during study. No difference in incidence of side effects in between two groups. Conclusion: Patients were haemodynamically stable throughout the study in both the groups.

Published
2019-08-11
How to Cite
Rani BN, A., & Bhatt, S. (2019). Haemodynamic Stability and Side Effects of Granisetron and Granisetron Dexamethasone Combination. Academia Anesthesiologica International, 4(2), 84-90. Retrieved from https://aijournals.com/index.php/aan/article/view/876