A Comparative study of Agomelatine and Ramelteon for Attenuation of Haemodynamic response to Laryngoscopy and Endotracheal Intubation
Attenuation of Haemodynamic response to Laryngoscopy and Endotracheal Intubation
Background: Pressor response to laryngoscopy and endotracheal intubation is a well recognised clinical entity, and many medications have been used for its attenuation. Agomelatine and Ramelteon are analogues of Melatonin which have been recently used for preoperative anxiolysis and sedation with less known effects on pressor response. Subjects and Methods: 60 ASA-I patients scheduled for elective surgeries under general anaesthesia were randomly allocated into 2 equal groups. Group-A (Tab.agomelatine 10 mg) and Group-R (Tab.ramelteon 8mg) were administered per oral 1 hour prior to induction of anaesthesia. Heart rate and blood pressure were assessed preoperatively and at 0,1,3,5,10,15 minutes. Results: Reduction heart rate and blood pressure were noted when compared to baseline in both the groups(p<0.05). However there was no statistical difference between the two groups at various intervals of time and were comparable (p>0.05). Conclusion: Oral agomelatine and ramelteon when administered 1 hour prior to induction of anaesthesia, resulted in comparable reduction of heart rate and blood pressure response to laryngoscopy and endotracheal intubation.