Oral Pregabalin vs Oral Hormone in An Exceedingly Attenuation of Hemodyanamic Response to Laryngoscopy Insertion, Extubation in Patients Undergoing Laparoscopic Cholecystectomy

Attenuation of Hemodyanamic Response

Abstract

Background: Premedication in the form of vasodilators, adreno receptor blockers, calcium channel blockers and opioids were used earlier to attenuate these responses, with variable results. This study will be conducted to evaluate & compare efficacy of oral pregabalin & oral melatonin in attenuation of haemodynamic responses during laryngoscopy, intubation & extubation in laparoscopic cholecystectomy. Subjects and Methods: This is a Prospective randomized double blind comparative study done on 60 Patients undergoing laparoscopic cholecystectomy in Department of Anesthesiology, Saraswathi Institute of Medical Sciences, Anwarpur, Hapur, Uttar Pradesh, India. All patients were explained about the anaesthesia technique and written informed consent taken. Group P - (30 patients) oral pregabalin 150mg, 120 min before surgery and Group M- (30 patients) oral melatonin tablets 6 mg (two tablets of 3 mg), 120 min before surgery. Pre-anaesthetic evaluation was done a day prior. Patients to be kept NPO 8 hours prior to surgery. Results: Our study showed that the mean age of patients was 36.5012.01 years in group P and 34.7014.82 years in group M, but statistically non-significant (P=0.6073). The heart rate, SBP, DBP & Mean arterial pressure was statistical non-significant. The complications occurred more in group P as compare to group M. The bradycardia, headache was more common complications in both groups. Conclusion: We concluded that both the drugs can be used as an effective premedicant to attenuate the sympathetic response to laryngoscopy and tracheal intubation without much side effects and the added advantage of intraoperative and postoperative analgesia.