A Comparative Study of Intrathecal 0.5% Hyperbaric Bupivacaine with Magnesium Sulfate versus 0.5% Hyperbaric Bupivacaine with Normal Saline in Elective Caesarean sections

Intrathecal 0.5% Hyperbaric Bupivacaine with Adjuvant

Abstract

Background: Aim: The aim of study was to compare intrathecal 0.5% hyperbaric bupivacaine with magnesium sulfate versus 0.5% hyperbaric bupivacaine with normal saline in elective caesarian sections. Subjects and Methods: The study was cross sectional study, total sample size of 60 patients taken randomly who are undergoing Caesarean section and divided into two groups Group M (30) and Group N (30). Group M and Group N with equal number of subjects and to Group M given Inj 0.5% hyperbaric bupivacaine 2cc (10mg) + 0.1cc of Magnesium sulfate and to Group N we given Inj 0.5% hyperbaric bupivacaine 2cc (10mg) + 0.1cc of Normal saline. Results: The mean age in MgSo4 + Bupivacaine group was 25.99 years and the SD was 4.22, in the Bupivacaine + Saline water group the mean age was 27.59 years and the SD was 4.56. The distribution of study samples by age groups was similar in the both groups (p=0.39).The mean age in the three groups is comparable (t-2.00, P-0.16). Conclusion: We conclude that Magnesium sulphate is very effective if used as an adjuvant to Bupivacaine in spinal anaesthesia as there is delayed onset of sensory block compared to Bupivacaine+ Normal saline, increased duration of 4 dermatome block regressions, increased duration of motor block and significant higher duration of effective analgesia without any alteration of hemodynamic parameters.