To Determine the Effect of Clonidine as an Adjuvant for Ropivacaine in Lower Limb Orthopedic Surgery

Clonidine as an Adjuvant for Ropivacaine

Abstract

Background: The present study determined the effect of Clonidine as an adjuvant for ropivacaine in lower limb orthopedic surgery. Subjects and Methods: The present study was conducted o 60 patients undergoing lower limb surgery. Group I patients were given 30 mL 0.75% ropivacaine alone for sciatic femoral block with Group II patients in whom sciatic femoral block will be achieved using 30 mL 0.75% Ropivacaine plus 1 g/kg clonidine. The time for the first rescue analgesia in the post-operative period, SBP, DBP sedation was assessed by a modified Ramsay sedation scale. Results: Group I comprised of 16 males and 14 females and group II had 18 males and 12 females. The difference was non- significant (P> 0.05). ASA grade I was seen 18 patients in group I and 24 in group II, ASA II was seen in 12 in group I and 6 in group II patients. The difference was non- significant (P> 0.05). Intra- operative variations in the mean arterial pressure (mmHg) between the cases of the two groups were significant at 5 min, 10 min,15 min & 60 min during the operation as P<0.05.  Post-operative variations in the mean systolic blood pressure (mm of Hg) between the cases of the two groups was not significant at time intervals as P>0.05. The difference in the sedation score between the cases of the two groups was highly significant at time intervals of 1 hour, 2 hours, 3 hours, 8 hours and Immediately post-op as P<0.001 & it was significant at time interval of 6 hr as p<0.05. Conclusion:  Authors found that clonidine added to ropivacaine 0.75% in an appropriate technique has low side effect profile with considerable therapeutic benefit and enhances the quality of combined sciatic femoral nerve block.