Effect of Preemptive Intravenous Paracetamol on Post-Operative Analgesic Requirement in Subjects Undergoing Laparoscopic Cholecystectomy Under General Anaesthesia with Placebo Controlled Trial

Preemptive Intravenous Paracetamol on Post-Operative Analgesic Requirements

Abstract

Background: Present study was done to assess the outcome of preemptive intravenous paracetamol on post-operative analgesic necessity in subjects undergo laparoscopic cholecystectomy undergoing General Anaesthesia (GA) through placebo controlled trial. Subjects and Methods: Current research performed in the Department of Anesthesiology, at Tertiary care institute of India for the period of 1 year. 150 subjects undergo laparoscopic cholecystectomy underneath GA by period of fewer than or equivalent to 90 mins were incorporated in research. Subjects were arbitrarily allocated into 3 groups: Group I: Got IV paracetamol 1 g (100 ml) 30 min earlier to beginning, with Hundred ml of IV normal saline earlier to closure of skin. Group II: got hundred ml IV normal saline 30 min prior to introduction, and IV paracetamol 1 g previous to closure of skin. Group III: Getting hundred ml IV normal saline 30 min prior to introduction, and previous to shutting of skin. All groups Comprise of 50 subjects each. Results: Mean VAS scores were considerably superior in group II (2.840.85) at 2 hours as contrast to Group I (2.460.30). Mean pain score was considerably superior in Group III at 15 minutes and 2 hours compare evaluate to Group I.  Conclusion: Preemptive organization of 1gram of IV paracetamol in subjects undergo laparoscopic cholecystectomy offer superior eminence analgesia with reduced pain scores through the postoperative era, improved subject approval and reduced post-operative Fentanyl use.