Randomized Controlled Trial to Evaluate Efficacy of Atracurium and Cis-Atracurum in Patients in Laparoscopic Surgery at Tertiary Care Center

Efficacy of Atracurium and Cis-Atracurum in Patients in Laparoscopic Surgery

  • Jayendrakumar C. Makwana Associate Professor, Department of Anaesthesia, GMERS Medical College and Hospital, Sola, Ahmedabad, Gujarat, India
  • Arpit Shah Senior Resident, Department of Anaesthesia, Smt B K Shah Medical Institute and Research Center, Ahmedabad, Gujarat, India
  • Achyut Bharatkumar Faldu Second Year Resident, Department of Anaesthesia, GMERS Medical College and Hospital, Sola, Ahmedabad, Gujarat, India
  • Pinal Vasani Third Year Resident, Department of Anaesthesia, GMERS Medical College and Hospital, Sola, Ahmedabad, Gujarat, India
Keywords: Atracurium, Cisatracurium, Muscle relaxants, Propofol

Abstract

Background: Muscle relaxants are used routinely during intubation to relax muscles in the neck and throat, which reduces the risk of injury. They may also be used to relax the chest muscles when an endotracheal tube is used to help mechanical ventilation. This study is designed to compare the efficacy of atracurium and cisatracurium by the means of: Onset of action, Hemodynamic stability and Duration of action. Subjects and Methods: Present Experimental Randomized controlled trial was done at the Department of Anaesthesiology, GMERS Medical College, Sola, Ahmedabad from July 2018 to July 2020 in 80 patients aged between 20 and 45 years. Study was performed in 80 patients aged 20-45 years weighted 40-70 kilograms with ASA physical grading 1 and 2 of either sex scheduled for elective laparoscopic surgery. Monitoring – ECG, non-invasive blood pressure, pulse oximetry, temperature and capnography (EtCO2). In operation theatre intravenous cannula of proper size was inserted into the largest vein on the forearm and an infusion of lactated ringer’s solution was started at a rate of 5 ml/kg/hr. Induction – inj. Propofol 2 mg per kg. Patients were divided into 2 groups: Group 1 - 40 patients were given atracurium 0.5 mg per kg for induction. Group 2 - 40 patients were given cisatracurium 0.1 mg per kg for induction. Results: No significant difference was found in both of the groups in measures of age, sex and weight. Onset of atracurium’s action is 3 minutes where as that is 5 minutes for cisatracurium. Using the Cooper’s scoring system, we can easily state that vocal cord movement was still present after 3 minutes of administration of cisatracurium whereas it was absent after     3 minutes of administration of atracurium. Conclusion: This randomized control study of 80 patients with 40 in each group was performed to evaluate efficacy of atracurium and cisatracurium in patients in laparoscopic surgery. From our results, we can conclude that, Onset of action is faster with atracurium than cisatracurium, Duration of action of cisatracurium is longer than atracurium and Hemodynamic stability is more with cisatracurium than atracurium. So, we can say that efficacy of cisatracurium is more than atracurium.

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Published
2021-12-31
How to Cite
Jayendrakumar C. Makwana, Shah, A., Achyut Bharatkumar Faldu, & Vasani , P. (2021). Randomized Controlled Trial to Evaluate Efficacy of Atracurium and Cis-Atracurum in Patients in Laparoscopic Surgery at Tertiary Care Center. Academia Anesthesiologica International, 6(2), 65-70. Retrieved from https://aijournals.com/index.php/aan/article/view/2208
Section
ORIGINAL ARTICLE