Comparison Between the Intravenous Ramosetron and Ondansetron in Prevention of Post-Operative Vomiting and Nausea in Adults Under General Anesthesia

Prevention of Post-Operative Vomiting and Nausea in Adults Under General Anesthesia

Abstract

Background: Present study was performed as randomized controlled trial to contrast the therapeutic efficiency of ramosetron and ondansetron for the management of recognized PONV in Subjects subsequent surgery under general anesthesia. Subjects and Methods: The Subjects will be separated into 2 groups of 100 each, in a random, single blinded mode. Group I received Ramosetron 0.3 mg I.V and Group II received Ondansetron 4 mg I.V. Postoperatively, Subjects were calculated for episodes of nausea, retching and vomiting and the need for rescue antiemetic at intervals of 0-2 hours, 2 -12 hours, 12 - 24 hours and 24 - 48 hours. Results: In this study, complete response was noted to be 60% in the Ondansetron group and 82% in the Ramosetron group. The requirement of rescue medication was less in the Ramosetron group compared to the Ondansetron group (2% vs. 14%). Conclusion: It is concluded from this study that Ramosetron 0.3 mg is safe and well-tolerated and additional effectual than Ondansetron 4 mg in the prevention of postoperative nausea and vomiting.