Clinical Assessment of Cardiovascular E?ects and Intubating Conditions with Rocuronium, Vecuronium, and Suxamethonium

Assessment of Cardiovascular Effects and Intubating Conditions

Abstract

Background: Achieving muscle relaxation during endotracheal intubation is a vital requirement and needs drugs safer than suxamethonium that is early-onset, long duration, stable hemodynamic parameter, minimum side effects, and good intubating conditions. The aims the present study was conducted to evaluate cardiovascular effects and intubating conditions of drug rocuronium compared to vecuronium and suxamethonium. Subjects and Methods: A total of 120 subjects were randomly divided into 3 groups of 40 subjects each depending on muscle relaxant given during intubation as Group I with 0.6 mg/kg rocuronium, Group II with 1.5 mg/kg suxamethonium, and Group III with 0.08 mg/kg vecuronium. Premedication was done with 0.2 mg glycopyrrolate and the anesthetic agent used was 4-5 mg/kg thiopentone sodium 2.5% along with the intermitted injection of vecuronium. Parameters assessed were fasciculations, cardiovascular response, limb movement, coughing, vocal cord movement and position, jaw relaxation, and apnoea onset. Results: For Group I, onset was longer compared to Group II, however, it was lesser than Group III. No fasciculation was seen in Group I and III but was seen in Group II. Better intubating conditions were seen in Group III.    No complication was seen in any subject from any group. Conclusion: The present study concludes that rocuronium is an effective and safer alternative to suxamethonium in tracheal intubation cases in subjects not needing rapid spontaneous respiration return. Hence, it can act as a filler between non-depolarizing neuromuscular blocking agents and suxamethonium and can be considered as the ideal neuromuscular agent.