A Randomized Double Blind Comparative Study of Intravenous Magnesium Sulphate and Intravenous Lignocaine for Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation

Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation

  • Penke S.V. Ramarao Professor and HOD, Department of Anesthesiology, Tirumala Multi Speciality Hospital Pvt. Ltd., Vizianagaram, Andhra Pradesh, India
  • T. Ramesh Kumar Junior Consultant, Department of Anesthesiology, Tirumala Multi Speciality Hospital Pvt. Ltd., Vizianagaram, Andhra Pradesh, India
  • D. Venkatesh Post Graduate, Department of Anesthesiology, Tirumala Multi Speciality Hospital Pvt. Ltd., Vizianagaram, Andhra Pradesh, India
Keywords: Intravenous magnesium sulphate, Lignocaine hydrochloride

Abstract

Introduction: Endotracheal intubation has become a standard part of anaesthesia and critical care management. All of these operations can cause sympathetic responses, and it’s important to remember that many of these patients are extremely ill and at risk. The aim is to compare the efficacy of intravenous Magnesium sulphate with intravenous Lignocaine hydrochloride in attenuation of cardiovascular responses to laryngoscopy and intubation. Subjects and Methods : A Prospective Randomized Double Blind Study. The study was done in General Operation Theatre Complex of the Tirumala Hospitals, Vizianagaram, Andhra Pradesh.70 Patients, 35 in each group. The study comprised patients who were scheduled for ASA class I and II elective surgical operations under general anaesthetic. Results: Percent rise in the HR, SBP, DBP, and MAP were significantly less in Group B(magnesium) compared to Group A(lignocaine). MgSO4 30mg/kg given intravenous 90 seconds prior to laryngoscopy and intubation for attenuation of pressor response results in significant reduction in HR, SBP, DBP and MAP at 1 min after laryngoscopy and intubation and no significant changes after 3 min when compared to intravenous lignocaine 1.5mg/kg. Conclusion: Intravenous magnesium sulphate 30mg/kg 90 seconds prior to laryngoscopy and intubation is superior to lignocaine 1.5mg/kg prior to laryngoscopy and intubation.

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Published
2021-12-31
How to Cite
Penke S.V. Ramarao, T. Ramesh Kumar, & D. Venkatesh. (2021). A Randomized Double Blind Comparative Study of Intravenous Magnesium Sulphate and Intravenous Lignocaine for Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation. Academia Anesthesiologica International, 6(2), 26-33. Retrieved from https://aijournals.com/index.php/aan/article/view/2179
Section
ORIGINAL ARTICLE