A Randomized Double Blind Comparative Study of Intravenous Magnesium Sulphate and Intravenous Lignocaine for Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation

Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation

Abstract

Introduction: Endotracheal intubation has become a standard part of anaesthesia and critical care management. All of these operations can cause sympathetic responses, and its important to remember that many of these patients are extremely ill and at risk. The aim is to compare the efficacy of intravenous Magnesium sulphate with intravenous Lignocaine hydrochloride in attenuation of cardiovascular responses to laryngoscopy and intubation. Subjects and Methods : A Prospective Randomized Double Blind Study. The study was done in General Operation Theatre Complex of the Tirumala Hospitals, Vizianagaram, Andhra Pradesh.70 Patients, 35 in each group. The study comprised patients who were scheduled for ASA class I and II elective surgical operations under general anaesthetic. Results: Percent rise in the HR, SBP, DBP, and MAP were significantly less in Group B(magnesium) compared to Group A(lignocaine). MgSO₄ 30mg/kg given intravenous 90 seconds prior to laryngoscopy and intubation for attenuation of pressor response results in significant reduction in HR, SBP, DBP and MAP at 1 min after laryngoscopy and intubation and no significant changes after 3 min when compared to intravenous lignocaine 1.5mg/kg. Conclusion: Intravenous magnesium sulphate 30mg/kg 90 seconds prior to laryngoscopy and intubation is superior to lignocaine 1.5mg/kg prior to laryngoscopy and intubation.