Norepinephrine and Phenylephrine for the Treatment of Hypotension During Spinal Anesthesia for Caesarean Section:

Gagan Deep  Singh; Atanu  Mukherjee; Deepika  Bagga

Gagan Deep Singh Associate Professor, Department of Anesthesia, Muza?arnagar Medical College, Muza?arnagar, Uttar Pradesh, India
Atanu Mukherjee Associate Professor, Department of Anesthesia, Muza?arnagar Medical College, Muza?arnagar, Uttar Pradesh, India
Deepika Bagga Final year MD Student, Department of Anesthesia, Muza?arnagar Medical College, Muza?arnagar, Uttar Pradesh, India

Keywords: Cardiac output, cesarean section, Systolic blood pressure, Stroke volume

Abstract

Background: To compare norepinephrine and phenylephrine for the treatment of hypotension during spinal anesthesia for caesarean section. Subjects and Methods: 104 American Society of Anesthesiologists I or II, primiparity, singleton, term pregnancy, elective caesarean section scheduled for spinal anesthesia were divided into two groups viz. Group P (phenylephrine) and group N (Norepinephrine). Following parameters such as systolic BP (SBP), Systolic blood pressure; HR: Heart rate; incidence of requirement for extra bolus, time to first extra bolus, and frequency of extra bolus, incidence of bradycardia was recorded. Results: The incidence of nausea, vomiting and dizziness was higher in group N as compared to group M. A significant difference was observed in two groups (P< 0.05). Time to first extra bolus was 5.2 minutes in group N and 5.7 minutes in group M, frequency of extra bolus was seen 1 in each group and incidence of bradycardia was seen among 2 in group N and 8 in group M. A non- significant difference was observed (P> 0.05). Conclusion: A greater SBP and a lower incidence of bradycardia with norepinephrine compared to phenylephrine for the management of maternal hypotension during elective cesarean section with spinal anesthesia.

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