Characteristics and Outcomes of Breast Cancer- Retrospective Analysis from a Tertiary Center in India.

Characteristics and Outcomes of Breast Cancer

Abstract

Background: Breast cancer is the most common cancer among women in India and globally and the  leading cause of cancer mortality among females. In India, the locally advanced breast cancer (LABC) constitutes 50 to 60% of the patients with Luminal A and Luminal B subtype, 16.7% HER2neu positive and 29.8% triple negative. Subjects and Methods: Breast cancer treated in the Department of Medical Oncology, RGGGH, Chennai from January 2014 to December 2016 were included in the study. Six hundred and twelve early and LABC patients were analyzed. Results: Among 612 patients, 315 (42.8%) were had early breast cancer and 297 (40.4%) were had locally advanced breast cancer. Among them 30.7% luminal subtype, 11.4% triple positive, 13.7% HER2 positive, 25.6% triple negative and 17.5% had unknown status. The overall mean DFS and OS in early breast cancer was 57months and 58 months respectively and locally advanced breast cancer was 51months and 52.5 months respectively. Discussion: Prevalence of TNBC in India is considerably higher compared with Western populations with Indian trial having 51.2% HR positive tumors, HER2 positive tumors in 16.7% and TNBC in 29.8%. In our study, 30.7% Luminal subtype, 11.4% triple positive, 13.7% HER2 positive, 25.6% triple negative and 17.5% had unknown status. The overall mean DFS and OS in early breast cancer was 57months and 58 months respectively and locally advanced breast cancer was 51months and 52.5 months respectively. Conclusion: In our study we found that most of our patients present with advanced disease and TNBC and HER2 positive disease compared to western countries. In our study we found the survival of our patients was comparable with our Indian survival data, but less than western patients.