Evaluation of Serum Leptin Level and BMI in Diabetic Patients: An Institutional Based Study:

Anil Kumar; Sangeeta Kapoor

Anil Kumar Assistant Professor, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India.
Sangeeta Kapoor Professor, Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India.

Keywords: BMI, Type 2 DM, Leptin, Obese, HbA1c

Abstract

Background: Diabetes mellitus is one of the major public health problems these days. Diabetes is a metabolic diseases characterized by hyperglycemia. Micro vascular and macrovascular complications of diabetes mellitus are very common. Leptin is a protein which is released from adipose tissue. Leptin can have a significant role in pathogenesis of diabetes. Aim: The objective of this study was to evaluate the variation in serum leptin levels in type 2 diabetes mellitus and control group. Subjects and Methods: The study group consisted of 100 patients. 50 patients of type 2 DM and 50 normal healthy controls were selected for the study. Blood glucose (FBS and PPBS), HbA1c, Serum lipids and lipoproteins, Serum leptin, and Body mass index (BMI) were estimated type 2 DM patients and normal healthy controls. Results: In group 1 (healthy individuals), BMI was 23.6 2.1 and in group 2 (type 2 DM patients), it was found to be 26.1 2.1. A statistically significant difference was observed in BMI of both groups. Serum leptin level in group 1 was found to be 5.422.22 and in group 2 it was found to be 9.22 1.82. A highly significant difference was observed in leptin level in both groups p<0.0001. Conclusion: We concluded that serum leptin levels are higher in patients suffering from Type 2 diabetes mellitus and it is strongly correlated positively with BMI.

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