A Study on Sub Clinical Hypothyroidism in Pregnancy

Sub Clinical Hypothyroidism in Pregnancy

Abstract

Background: Subclinical hypothyroidism and hypothyroidism are common endocrinological disorder which affects mothers during pregnancy. It effects foetus also.Thyroid hormone screeching especially TSH (Thyroid stimulating hormone) and FT4 is important before pregnancy as thyroid hormone levels have important role for neurophysiological development of baby. Subjects and Methods: We have conducted this study on 435 antenatal women with 34-38 weeks of gestation. Detailed history was taken and clinical examination was done. Blood samples were send to serum TSH and FT4 measurement. Subclinical hypothyroidism was noted in 18 mother s and they were compared with 55 euthyroid pregnant women. Mothers were followed up till discharge from hospital new born weight, abgarscore and serum TSH after 48 hours of birth to 7 days was measured. Aim of the study: To study the prevalence and complications of subclinical hypothyroidism in pregnant women and new born. Results: In our study the prevalence of subclinical hypothyroidism was 4.15% complication of subclinical hypothyroidism were pre-eclampsia 13.25%, and abruption placenta 6.48%; foetus complications in subclinical hypothyroidism include low birth weights 28.12%; Intra uterine growth retardation 12.8%; still had born 12.6%; Jaundice 11.24% subclinical hypothyroidism in pregnancy is associated with neo natal complications and maternal complications. Conclusion: Subclinical hypothyroidism is associated with maternal and foetus complications. Screening for serum TSH and FT4 is essential to prevent the maternal and foetus complications.