Assessment of Serum Total IgE Levels in Smokers, Non- Smokers and Ex-Smokers and its Relation to Lung Function

Serum Total IgE Levels in Smokers, Non- Smokers and Ex-Smokers

Abstract

Background: The aim is to assess serum total IgE levels in smokers, non- smokers and ex- smokers and its relation to lung function. Subjects and Methods: One hundred forty subjects of either gender was included and they were divided into three groups such as group I comprised of smokers, group II non- smokers and group III ex- smokers. Weight and high was recorded followed by BMI. History of alcohol intake was also recorded. 5 ml of venous blood was taken for assessment of haemoglobin, ESR and absolute haemoglobin count. IgE level was assessed using ELISA. Results: There were 52 males and 18 females in group I, 14 males and 16 females in group II and 25 males and 15 females in group III. The mean weight (kg) in group I, group II and group III were 68.2, 65.4 and 64.7, mean height (cm) was 170.2, 171.4 and 169.4, mean BMI (Kg/cm2) was 24.6, 23.2 and 23.7 and alcohol (>once /month) was seen among 42, 8 and 23 respectively. The mean IgE (IU/ml) level was 346.8 in group I, 32.4 in group II and 204.6 in group III. The absolute eosinophil count/mm3 was 310.2 in group I, 192.6 in group I and 284.5 in group III. Breath CO (ppm) level was 15.4 in group I, 4.3 in group II and 5.2 in group III. The mean FVC (%) was 84.1, 94.2 and 74.7, FEV1 (%) was 71.4, 94.2 and 52.2, FEV1/ FVC was (%) 84.3, 98.4 and 67.5, FEF25-75 (%) was 56.3, 94.2 and 38.6 and FEF max (%) was 75.4, 10.4.3 and 47.9 in group I, group II and group III respectively. Conclusion: The high level of IgE and altered pulmonary function tests in smokers and ex- smokers as compared to non- smokers show direct relationship.