Assessing the Predictive Value of Serum Bilirubin before 6 Hours of Life for Subsequent Hyperbilirubinemia in Healthy Term Neonates

Hyperbilirubinemia in Term Neonates

  • G R Sunilkumar Associate Professor, Department of Paediatrics, Subbaiah institute of Medical Sciences, Shivamogga, Karnataka, India
  • K. Muralidhar Associate Professor, Department of Pediatrics, Kamineni Institute of Medical Sciences, Narketpally, Telangana, India
Keywords: Bilirubin, Hyperbilirubinemia, Vaginal

Abstract

Background: Hyperbilirubinaemia, presenting as jaundice, is a ubiquitous and frequently benign condition in newborn babies but is a leading cause of hospitalisation in the first week of life. The present study was conducted to assess the predictive value of serum bilirubin before 6 hours of life for subsequent hyperbilirubinemia in healthy term neonates. Subjects & Methods: The study was conducted at Department of Pediatrics in a tertiary care hospital from April 2020 to September 2020 among 74 term neonates of both genders were recruited. Total serum bilirubin, direct and indirect bilirubin was estimated first, within 6 hours of life and second, after 72 hours of life by Modified Van den Bergh’s kit method. Results: Vaginal delivery was seen in 56 and cesarean in 18, parity 1 was present in 40, 2 in 24 and >2 in 10, blood group A was present in 9, B in 15, AB in 20 and O in 28. The mean TSB level (mg/dl) between 2.6- 4.0 was seen in 30, 4.1- 5.5 in 34 and >5.6 in 10 patients. TSB level (mg/dl) between 7.7-10.2 was seen in 7, 10.3-12.7 in 18, 12.8-15.3 in 36 and >15.4 in 13 patients. Hyperbilirubinemia was seen in 2 with bilirubin level between 2.6-4, in 4 with bilirubin level between 4.1-5.5 and 6 with bilirubin level >5.6. The difference was significant (P< 0.05). Conclusion: Total serum bilirubin level of >5 mg/dL within 6 hours of birth may be considered as a predictor for risk of subsequent hyperbilirubinemia

Downloads

Download data is not yet available.

References

Mishra S, Agarwal R, Deorari AK, Paul VK. Jaundice in the newborns. Indian J Pediatr. 2008;75(2):157–163. Available from: https://dx.doi.org/10.1007/s12098-008-0024-7.

Porter ML, Dennis BL. Hyperbilirubinaemia in the term newborn. Am Fam Physician. 2002;65(4):599–607.

Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297–316. Available from: https://doi.org/10.1542/peds.114.1.297.

Kramer LI. Advancement of Dermal Icterus in the Jaun-diced Newborn. Am J Dis Child. 1969;118(3):454–

Available from: https://dx.doi.org/10.1001/archpedi.1969.02100040456007.

Puppalawar PV, Goswami K, Dhok A. Review on “Evolution of methods of bilirubin estimation”. J Dent Med Sci. 2012;1(3):17–28.

Barrington KJ, Sankaran K, and. Guidelines for detection, management and prevention of hyperbilirubinemia in term and late preterm newborn infants. J Paediatr Child Health. 2007;12:1–12. Available from: https://dx.doi.org/10.1093/pch/12.suppl_b.1b.

Bhutani VK, Johnson L, Sivieri EM. Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns. Pediatrics. 1999;103(1):6–14. Available from: https://dx.doi.org/10.1542/peds.103.1.6.

Alpay F, Sarici SÜ, Tosuncuk HD, Serdar MA, Inanç N, Gökçay E. The Value of First-Day Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Term Newborns. Pediatrics. 2000;106(2):16. Available from: https://dx.doi.org/10.1542/peds.106.2.e16.

Agarwal R, Kaushal M, Paul VK. Early neonatal hyperbiliru- binaemia using first day serum bilirubin level. Indian Paediatr. 2002;39:724–754.

Randev S, Grover N. Predicting neonatal hyperbilirubinemia using first day serum bilirubin levels. Indian J Pediatr. 2010;77(2):147–150. Available from: https://dx.doi.org/10.1007/s12098-009-0335-3.

Bandi C, Vanaki R, Badakali AV, Pol RR, Yelamali B. Predictive value of total serum bilirubin within 6 hours of birth for the development of hyperbilirubinemia after 72 hours of birth. J Clin Diagn Res. 2016;10(9):1–4. Available from: https://doi.org/10.7860/jcdr/2016/16314.8460.

Olusanya BO, Kaplan M, Hansen TWR. Neonatal hyperbiliru- binaemia: a global perspective. Lancet Child Adolesc Health.

Published
2020-12-28
How to Cite
G R Sunilkumar, & K. Muralidhar. (2020). Assessing the Predictive Value of Serum Bilirubin before 6 Hours of Life for Subsequent Hyperbilirubinemia in Healthy Term Neonates. Asian Journal of Clinical Pediatrics and Neonatology, 8(4), 41-44. Retrieved from http://aijournals.com/index.php/ajcpn/article/view/1879
Section
Original Article