Asian Journal of Clinical Pediatrics and Neonatology <p><strong class="pull-left">Asian Journal of Clinical Pediatrics and Neonatology (AJCPN)</strong>&nbsp;&nbsp;is an open-access; freely accessible, online and print Quarterly peer-reviewed international journal publishes a wide spectrum of advanced research in different fields of pediatrics and neonatology, covering etiology, diagnosis, therapy and prognosis aspects. <br> <strong>Online ISSN: 2347-3363 | Print ISSN: 2347-3355</strong></p> en-US (Dr. Rohit Varshney) Sun, 01 Dec 2019 03:53:52 +0000 OJS 60 Role of Otoacoustic Emissions and Auditory Brainstem Response for Early Detection of Hearing Loss in Children 0-3 Months of Age <p><strong>Background: </strong>Hearing impairment has a huge adverse impact on the normal developmental outcome of an individual. The various newborn period risk factors may escalate hearing loss. Early detection of hearing impairment has been made possible with the use of universal tools like OAE (Otoacoustic emission) and ABR (Auditory brainstem response) and has resulted in the general awareness and timely intervention. This study highlights the use of OAE and ABR for early detection of hearing loss in children 0-3 months along with the associated risk factors taken into consideration.<strong>Subjects and Methods: </strong>The present study was conducted in Maharishi Markandeshwar medical college and hospital over a period of 12 months and included 1680 newborns who were subjected to two staged OAE examination( pre discharge and at 6 weeks) followed by ABR examination done over a period of 3 months. The various risk factors were also evaluated.<strong>Results: </strong>A total of 1680 newborns underwent pre discharge first OAE examination, 146(8.7%) failed. A total of 141 underwent the repeat OAE examination at 6 weeks and 23(16.3%) failed. ABR examination of 20 children resulted in failure in 3(15%) culminating in overall prevalence of hearing impairment of 1.79 per 1000 population. The prevalence of various risk factors taken into consideration was 23%.<strong>Conclusion: </strong>The two staged sequential OAE assessment followed by ABR examination has an important role for the early detection of hearing impairment and consequent improvement in the quality of life. This should be adopted by all the newborn care providers as a part of their routine examination of the newborns.</p> Hemant Gupta, Smriti Anand, Neelam Grover, Vipen Gupta, Deepika Sharma Copyright (c) 2019 Asian Journal of Clinical Pediatrics and Neonatology Sun, 01 Dec 2019 00:00:00 +0000 Magnitude of Bacteriological Etiology in Acute Encephalitis Syndrome: A Cross-Sectional Study <p><strong>Background: </strong>Meningoencephalitis is an acute purulent infection within the subarachnoid space, it is associated with a CNS inflammatory reaction i.e. inflammation of brain and parenchyma both that may result in decreased consciousness, seizures, raised intracranial pressure and stroke. The present study was aimed to know the magnitude of bacteria that making picture of meningoencephalitis in AES among the children.<strong>Subjects and Methods: </strong>Present cross-sectional study was conducted in Children aged 1-15 yrs of age suffering from AES admitted in B.R.D Medical College, Gorakhpur.&nbsp; The study subject (children aged 1-15yrs suffering from AES) have been investigated for AES and bacterial etiology and subsequent comparison is made on the basic of clinical features, CSF findings and other lab findings. We divided our study in two parts, in first on the basic of our inclusion criteria we enrolled the patient and on a preplanned clinical proforma we did detailed clinical examination and investigate them accordingly. Cases with suspected AES were studied for their clinical features, recovery patterns and other biochemical and microbiological parameters. After the patient was admitted in the hospital, CSF, serum and stool samples were collected and stored at appropriate temperature. The samples were collected by resident doctor. <strong>Results: </strong>Out of 160 cases 16 case show culture positive result and among them Gm +vecocci was found in only 2 cases (2.5%). Gram negative cocci in 10(6.25%) cases and gram negative bacilli in 4 (2.5%) cases. The most common presenting symptoms were fever in 16 (100) cases followed by vomiting in 12 (75.00), headache in 10 (62.55) a seizure was in 10 (62.5) cases that was generalized tonic type. The CSF examination was suggestive that the majority of cases of AES were due to viral encephalitis. And 10%&nbsp; culture show&nbsp; positivity of&nbsp; bacteria in CSF . Meningeal sign like neck rigidity and kernign have significant association with bacterial culture positive result.<strong>Conclusion: </strong>The most common illness among AES patients observed in our study is Non-Bacterial but Japanese Encephalitis is still a problem in this region and it must not be neglected. Better diagnostic tests and standards to link an agent to encephalitis are needed in this field.</p> Prabhat Bhardwaj, Richa Tripathi Copyright (c) 2019 Asian Journal of Clinical Pediatrics and Neonatology Sun, 01 Dec 2019 00:00:00 +0000 Diagnostic Utility of Measuring First Day Serum Bilirubin Levels in Management of Neonatal Hyperbilurubinemia <p><strong>Background: </strong>Hyperbilirubinemia is the commonest finding in the first week of life, cause of concern for the parents and pediatricians. Objectives: With this study was carried to evaluate the predictive value of serum bilirubin level on day one postnatal age for identifying term neonates at risk for subsequent hyperbilirubinemia.<strong>Subjects and Methods: </strong>Study was conducted in GSL Medical College. Study protocol was approved by institutional ethics committee. Informed consent was collected from the parents / guardians of all the study participants. Neonates ≥ 37 weeks who were otherwise healthy were included in the study. First serum bilirubin measurement was estimated initially within 24±2 hours of life. Second serum bilirubin estimation estimation was attempted if clinical assessment of serum bilirubin &gt;10 mg/dl.<strong>Results: </strong>Total 200 healthy term newborns were evaluated; male female ratio was 1.2.&nbsp; The mean gestation period was 39.24±1.12 weeks. Maximum (58%; 116) women had full term normal vaginal delivery. The range of bilirubin on day one was 2.2 – 8.5mg/dl; majority newborns (86.5%) did not develop significant hyperbilirubinemia.<strong>Conclusion: </strong>Early screening and appropriate management of hyperbilirubinemia is needed for prevention of complications in the newborn. This decreases the significant burden of untreated severe neonatal jaundice, causing potential neurological sequelae.</p> R Rama Krishna Paramahamsa, Gangina Sriram, Swetha Koneru, T Jaya Chandra Copyright (c) 2019 Asian Journal of Clinical Pediatrics and Neonatology Sun, 01 Dec 2019 00:00:00 +0000 Prebiotics in Management of Neonatal Jaundice: Open Label Randomised Control Trial <p><strong>Background: </strong>Approximately 5-35% of neonates develop jaundice requiring treatment during the 1st week of life. Prebiotics, a mixture of Galacto-oligosaccharides (GOS) and Fructo-oligosaccharides (FOS), has been postulated to reduce serum bilirubin levels on principle of interruption of entero-hepatic circulation. Objective: To evaluate the effect of oral supplementation with prebiotics (Fructo-oligosaccharides) in the management of neonatal jaundice. <strong>Subjects and Methods: </strong>Design &amp; Setting: Open Label, Randomized Control Trial at Level II NICU in public hospital over one year. Participants: Term exclusively breast-fed neonates with Jaundice requiring phototherapy. Intervention: Randomisation of Sixty eligible neonates into Control and Prebiotic groups (n= 30 each). Both groups received phototherapy, and Prebiotic group received additional oral prebiotics.&nbsp; Outcome: Primary outcome measure was a reduction in total serum bilirubin levels (TSB) and duration of phototherapy. The secondary outcome measure was the change in the frequency of stools.<strong>Results: </strong>Baseline Features were similar in both groups. Overall serum bilirubin levels decreased significantly from enrolment till the omission of phototherapy (17.24 + 1.16 vs. 12.74 + 0.48; P: 0.00). ANOVA depicted no statistical difference between the groups in 12 hourly reductions of TSB (F [3, 232] = 0.14, P: 0.94). Mean duration of phototherapy (in hours) required in prebiotic and control group was similar (50.40 + 9.66 vs. 47.60 + 8.62; P = 0.24). Secondary outcome measures were also similar in both groups.<strong>Conclusion: </strong>Prebiotics, containing only fructo-oligosaccharides, administered for upto three days, do not have any additional effect on reduction of serum bilirubin levels in neonates with jaundice receiving conventional treatment.</p> Trupti Amol Joshi, Amol Kalyanrao Joshi, Laxmikant Sheshrao Deshmukh Copyright (c) 2019 Asian Journal of Clinical Pediatrics and Neonatology Sun, 08 Dec 2019 00:00:00 +0000