Asian Journal of Clinical Pediatrics and Neonatology <p><strong class="pull-left">Asian Journal of Clinical Pediatrics and Neonatology (AJCPN)</strong>&nbsp;&nbsp;is an open-access; freely accessible, online and print Quarterly peer-reviewed international journal publishes a wide spectrum of advanced research in different fields of pediatrics and neonatology, covering etiology, diagnosis, therapy and prognosis aspects. <br><strong>Online ISSN: 2347-3363 | Print ISSN: 2347-3355</strong></p> Society for Health Care & Research Development en-US Asian Journal of Clinical Pediatrics and Neonatology 2347-3355 Correlation of Hypoxic Ischemic Encephalopathy Stages with Clinical Variables <p><strong>Background: </strong>Injury to the CNS related with perinatal asphyxia is referred to as Hypoxic-Ischemic Encephalopathy which is the utmost severe neurological condition that arises in perinatal periods. The aim is to assess clinical variables with hypoxic-ischemic encephalopathy stages. <strong>Subjects and Methods: </strong>A clinical study of 42 new borns asphyxiated were assessed clinically of these asphyxiated neonates was carried out using Sarnath and Sarnath Staging of HIE. The association between asphyxia at birth and HIE has been examined. <strong>Results: </strong>In the present study, maternal history, gestational age, and mode of delivery were found to be not significant and do not correlate with the severity of HIE. Sarnath and Sarnath clinical scoring for neurobehavioral signs and symptoms 13 (31%) had reveal of HIE stage -1, 14 (33%) are of stage -2 and severe HIE (HIE-III) common, seen in 15cases (36%). The correlation of non-stress test (NST), Meconium staining was more in stage-3 in HIE stages and statistically significant. <strong>Conclusion</strong>: During the diagnosis and treatment of HIE patients, analysis of clinical variables will improve the objectivity of newborn assessment and evaluation and early start of care.</p> Manchala Chandra Sekhar Copyright (c) 2020 Author 2020-10-10 2020-10-10 8 3 1 6 Ferritin as a Marker of Severe Dengue in Children <p><strong>Background: </strong>The aim is to evaluate ferritin levels in fever caused by dengue virus and their association with the severity of infection with dengue virus in children. <strong>Subjects and Methods: </strong>It is a Prospective that was done for 1 year in the department of pediatrics. 56 reported cases with a history of dengue fever for clinical evaluation by positive IgG and IgM antibodies and positive NS1 antigen and were included in the sample. All 16-year-old subjects with clinical dengue suspicion presenting in the department of emergency. <strong>Results</strong>: Out of total of 56 children with mean age of the children were 11.5 years and SD 3.5 years, and 59% were male who were majority. Mean hospital stay duration was 5 3 days. Most of the patients in study discharged in 5-7 days of admission in hospital. The mean serum ferritin levels among cases with DHF were raised than those with DF with significant p-values of&lt; 0.05 on Day 5 and 6 of illness. During Days 5, 6, and 7 after the onset of fever, the results for sensitivity were 83, 86, and 92 per cent respectively. <strong>Conclusion</strong>: The incidence of hyperferritinaemia in patients infected with dengue virus is suggestive of highly active use of ferritin level in serum is 1,200 ng/ml as a method for predicting progression to DHF starting on Day 4 of the disease and continuing to recover.</p> Manchala Chandra Sekhar Copyright (c) 2020 Author 2020-10-10 2020-10-10 8 3 7 11 Profile of Children Presenting with Epilepsy at a Tertiary Care Centre: A Hospital Based Cross Sectional Study <p><strong>Background: </strong>Epilepsy is associated with significant mortality and morbidity. It is one of the common causes of childhood hospitalization. Regarding acute seizures episodes, there is limited data form the developing countries. This study aims to study the profile of children presenting with epilepsy at a Tertiary Care Centre. <strong>Subjects &amp; Methods: </strong>This was a hospital based, prospective cross-sectional study conducted at the ‘epilepsy clinic’ of Paediatric department of a Tertiary Care Center. Total 260 children with epilepsy and having the age of 1 months to 12 years attending to the epilepsy clinic during the study period, were studied for clinical features, types, imaging studies, EEG, etc. <strong>Results: </strong>Most of the children (59.61%) affected with epilepsy were males. Majority of the cases (108) were in the age group 1 month to 1 year age. It was observed that, 185 cases (71.15%) were born through pre term delivery. It was found that 214 cases (82.31%) had abnormal EEG, 40 cases had abnormal CT scan and 46 cases had abnormal MRI. A significant number of children (60.38%) had generalized tonic clonic seizures. <strong>Conclusion: </strong>Epilepsy in children is a common indication for hospital admission. Evaluation of the type of seizure type with specific EEG findings and other related investigations helps in early and appropriate initiation of treatment. It is utmost important that the children with seizures should be on regular long term follow up and treatment, for better prognosis and disease outcome.</p> Amol Ramrao Suryavanshi Sachin Bapurao Bodhgire Shivaji Sangappa Phulari Rahul Digambarrao Anerao Copyright (c) 2020 Author 2020-10-10 2020-10-10 8 3 12 16 Correlation of Cord Lactate with Cord pH as a Morbidity Predictor in Term Neonates Delivered with Non-Reassuring Fetal Heart Status <p><strong>Background: </strong>Perinatal asphyxia is accounting to 20% of neonatal mortalityin India. Cord lactate can be an alternative that is more readily available than cord pH and may help in early identification of birth asphyxia in resource limited settings. The aim of the current study is to correlate cord lactate levels with cord pH in term neonates with non-reassuring fetal heart status and thereby its use as a surrogate for cord&nbsp;&nbsp;&nbsp; pH. <strong>Subjects &amp; Methods: </strong>Study design: Cross-sectional study. Setting: Neonatology unit at NRI general hospital, Chinakakani from August 2018 to July 2019. Study participants: All singleton term neonates delivered by assisted vaginal delivery or emergency caesarean section due to non-reassuring fetal heart status. Umbilical cord blood gas and lactate was obtained. Lactate was analysed by colorimetric method. <strong>Results: </strong>A total of 74 neonates were included. An analysis of cord pH &amp; lactate, using correlation coefficient showed statistically significant p-values. Cord lactate was found to be statistically significant predictor for admission to NICU, post resuscitation care, invasive/noninvasive ventilation, and therapeutic hypothermia on multiple logistic regression analysis. Cord Lactate was found to have an Area under the curve (AUC) of 0.88 with no significant difference to cord pH on ROC curve analysis. <strong>Conclusion: </strong>Cord Lactate can be used as an objective test in predicting the neonates requiring NICU admission for morbidities related to fetal hypoxia similar to that of cord pH in term neonates.</p> Aluru Ananya Kanta Kumari PML B Vijayalakshmi R Chandrasekhar Naga Saritha Kolli Copyright (c) 2020 Author 2020-10-10 2020-10-10 8 3 17 22